Format

Send to:

Choose Destination

Drd1 dopamine receptor D1 [ Mus musculus (house mouse) ]

Gene ID: 13488, updated on 6-Sep-2021

Summary

Official Symbol
Drd1provided by MGI
Official Full Name
dopamine receptor D1provided by MGI
Primary source
MGI:MGI:99578
See related
Ensembl:ENSMUSG00000021478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drd; Drd-; Gpcr; Drd-1; Drd1a; Gpcr15; C030036C15Rik
Expression
Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.8) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Drd1 in Genome Data Viewer
Location:
13 B1; 13 28.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54205202..54209677, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54051183..54055658, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (54146552..54151027, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130119H09 gene Neighboring gene predicted gene, 34557 Neighboring gene sideroflexin 1 Neighboring gene ribosomal protein, large, P0 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (13)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables D3 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dopamine neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables dopamine neurotransmitter receptor activity, coupled via Gs IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gs IDA
Inferred from Direct Assay
more info
PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gs IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gs ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult walking behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dopamine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in grooming behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within histone H3-S10 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mating behavior IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modification of postsynaptic structure EXP
Inferred from Experiment
more info
PubMed 
acts_upstream_of_or_within muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within operant conditioning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in operant conditioning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to amphetamine IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensitization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striatum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cilium ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine neck ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D(1A) dopamine receptor
Names
D1 receptor
D1A dopamine receptor
G protein-coupled receptor DRD1
dopamine D1 receptor
dopamine receptor D1A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291801.1NP_001278730.1  D(1A) dopamine receptor

    See identical proteins and their annotated locations for NP_001278730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BE957273, BY298225, CT030176
    Consensus CDS
    CCDS26524.1
    UniProtKB/Swiss-Prot
    Q61616
    Conserved Domains (2) summary
    pfam00001
    Location:39331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40157
    7tm_4; Olfactory receptor
  2. NM_010076.3NP_034206.1  D(1A) dopamine receptor

    See identical proteins and their annotated locations for NP_034206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK044723, BE957273, BY287823, CT030176
    Consensus CDS
    CCDS26524.1
    UniProtKB/Swiss-Prot
    Q61616
    Related
    ENSMUSP00000021932.6, ENSMUST00000021932.6
    Conserved Domains (2) summary
    pfam00001
    Location:39331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40157
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54205202..54209677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center