Format

Send to:

Choose Destination

Dsg2 desmoglein 2 [ Mus musculus (house mouse) ]

Gene ID: 13511, updated on 23-Jun-2021

Summary

Official Symbol
Dsg2provided by MGI
Official Full Name
desmoglein 2provided by MGI
Primary source
MGI:MGI:1196466
See related
Ensembl:ENSMUSG00000044393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA408168; D18Ertd293; D18Ertd293e
Summary
This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]
Expression
Broad expression in large intestine adult (RPKM 25.2), colon adult (RPKM 24.6) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dsg2 in Genome Data Viewer
Location:
18 A2; 18 11.42 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (20691131..20737583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (20558074..20604526)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (20716617..20763027)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene triosephosphate isomerase related sequence 10 Neighboring gene predicted gene, 46630 Neighboring gene predicted gene 16090 Neighboring gene transthyretin Neighboring gene ribosomal protein L35 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in desmosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in desmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in desmosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007883.3NP_031909.2  desmoglein-2 preproprotein

    See identical proteins and their annotated locations for NP_031909.2

    Status: REVIEWED

    Source sequence(s)
    AC132091, AK029320, BG092030
    Consensus CDS
    CCDS29084.1
    UniProtKB/Swiss-Prot
    O55111
    Related
    ENSMUSP00000057096.9, ENSMUST00000059787.15
    Conserved Domains (1) summary
    cd11304
    Location:168273
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    20691131..20737583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center