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Adam24 a disintegrin and metallopeptidase domain 24 (testase 1) [ Mus musculus (house mouse) ]

Gene ID: 13526, updated on 23-Jun-2021

Summary

Official Symbol
Adam24provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 24 (testase 1)provided by MGI
Primary source
MGI:MGI:105984
See related
Ensembl:ENSMUSG00000046723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dtgn; Dtgn5
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Male mice lacking the encoded protein exhibit reduced fertility due to the higher incidence of polyspermic embryos. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Expression
Restricted expression toward testis adult (RPKM 17.4) See more
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Genomic context

See Adam24 in Genome Data Viewer
Location:
8; 8 A4
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41128118..41135238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40675077..40682199)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (41760448..41767553)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene high mobility group box 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prevention of polyspermy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm head plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 24
Names
a disintegrin and metalloproteinase domain 24 (testase 1)
disintegrin 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010086.5NP_034216.3  disintegrin and metalloproteinase domain-containing protein 24 preproprotein

    See identical proteins and their annotated locations for NP_034216.3

    Status: REVIEWED

    Source sequence(s)
    AK029528, AK133199, BB616396
    Consensus CDS
    CCDS22255.1
    UniProtKB/Swiss-Prot
    Q9R160
    UniProtKB/TrEMBL
    Q8CDV3
    Related
    ENSMUSP00000050727.4, ENSMUST00000051614.5
    Conserved Domains (4) summary
    smart00608
    Location:492628
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:209395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:415488
    Disintegrin
    pfam01562
    Location:42160
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41128118..41135238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509261.1XP_006509324.1  disintegrin and metalloproteinase domain-containing protein 24 isoform X1

    See identical proteins and their annotated locations for XP_006509324.1

    UniProtKB/Swiss-Prot
    Q9R160
    Conserved Domains (4) summary
    smart00608
    Location:492628
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:209395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:415488
    Disintegrin
    pfam01562
    Location:42160
    Pep_M12B_propep; Reprolysin family propeptide
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