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Adam24 ADAM metallopeptidase domain 24 [ Mus musculus (house mouse) ]

Gene ID: 13526, updated on 11-Apr-2024

Summary

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Official Symbol
Adam24provided by MGI
Official Full Name
ADAM metallopeptidase domain 24provided by MGI
Primary source
MGI:MGI:105984
See related
Ensembl:ENSMUSG00000046723 AllianceGenome:MGI:105984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dtgn5
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Male mice lacking the encoded protein exhibit reduced fertility due to the higher incidence of polyspermic embryos. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Expression
Restricted expression toward testis adult (RPKM 17.4) See more
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Genomic context

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Location:
8 A4; 8 23.89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41128118..41135238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40675077..40682199)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene STARR-seq mESC enhancer starr_21273 Neighboring gene high mobility group box 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testase 1 (ADAM 24) a plasma membrane-anchored sperm protease implicated in sperm function during epididymal maturation or fertilization. Zhu GZ, et al. J Cell Sci, 2001 May. PMID 11309208
  2. Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Zhu GZ, et al. Mol Reprod Dev, 2009 Nov. PMID 19670298
  3. Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. Zhu GZ, et al. Gene, 1999 Jul 8. PMID 10395895
  4. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article
  5. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within prevention of polyspermy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm head plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 24
Names
a disintegrin and metallopeptidase domain 24 (testase 1)
a disintegrin and metalloproteinase domain 24 (testase 1)
disintegrin 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010086.5 → NP_034216.3  disintegrin and metalloproteinase domain-containing protein 24 preproprotein

    See identical proteins and their annotated locations for NP_034216.3

    Status: REVIEWED

    Source sequence(s)
    AK029528, AK133199, BB616396
    Consensus CDS
    CCDS22255.1
    UniProtKB/Swiss-Prot
    A6H683, E9QL68, Q9R160
    UniProtKB/TrEMBL
    Q8CDV3
    Related
    ENSMUSP00000050727.4, ENSMUST00000051614.5
    Conserved Domains (4) summary
    smart00608
    Location:492 → 628
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:209 → 395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:415 → 488
    Disintegrin
    pfam01562
    Location:42 → 160
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41128118..41135238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509261.1 → XP_006509324.1  disintegrin and metalloproteinase domain-containing protein 24 isoform X1

    See identical proteins and their annotated locations for XP_006509324.1

    UniProtKB/Swiss-Prot
    A6H683, E9QL68, Q9R160
    UniProtKB/TrEMBL
    Q8CDV3
    Conserved Domains (4) summary
    smart00608
    Location:492 → 628
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:209 → 395
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:415 → 488
    Disintegrin
    pfam01562
    Location:42 → 160
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R160.2 GenPept UniProtKB/Swiss-Prot:Q9R160

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