Edn2 endothelin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Edn2provided by MGI
Official Full Name: endothelin 2provided by MGI
Primary source: MGI:MGI:95284
See related: Ensembl:ENSMUSG00000028635 AllianceGenome:MGI:95284
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VIC; ET-2; PPET2
Summary: This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a potent vasoconstrictive peptide. This gene is abundantly expressed in the gastrointestinal tract, strongly induced in photorecepteror cells in retinal diseases and injury, and produced by microglia and macrophages in the early stages of glaucoma. Mice lacking the encoded protein exhibit severe growth retardation, hypothermia and juvenile lethality. [provided by RefSeq, Feb 2016]
Expression: Biased expression in large intestine adult (RPKM 14.8), small intestine adult (RPKM 13.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 55.77 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (120018403..120024557)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (120161206..120167360)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelin ETA and ETB receptors seem to be involved in the oxaliplatin-induced peripheral sensory neuropathy in mice and they should be considered possible targets for the management of this clinical feature.
Title: Involvement of Endothelin Receptors in Peripheral Sensory Neuropathy Induced by Oxaliplatin in Mice.
Follicle rupture and fertility were significantly impaired in the absence of ovarian Edn2 expression.
Title: Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture.
The results demonstrated that long-term hyperglycaemia in conjunction with VEGF-driven retinal neovascularization increased Edn2 serum concentration suggesting Edn2 might be a candidate biomarker for vascular changes in diabetic retinopathy.
Title: Biomarkers for Diabetic Retinopathy - Could Endothelin 2 Be Part of the Answer?
EDN2 is necessary for normal ovulation and corpus luteum formation.
Title: Loss of function of endothelin-2 leads to reduced ovulation and CL formation.
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.
Title: Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.
Edn2-mediated mechanisms that contribute to PR survival
Title: Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.
ET-2 is critical for the growth and survival of postnatal mice and plays important roles in energy homeostasis, thermoregulation, and the maintenance of lung morphology and function.
Title: Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.
We conclude that constitutive overexpression of Norrin protects photoreceptors from light damage, an effect that is mediated by Wnt/beta-catenin and EDN2 signaling and involves neurotrophic activities of BDNF.
Title: Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage.
ET-2 acts in a cooperative manner with ET-1, giving to the villus the straight enough to withstand mechanical stress.
Title: Endothelin system in intestinal villi: A possible role of endothelin-2/vasoactive intestinal contractor in the maintenance of intestinal architecture.
Since endothelin 2 is potently vasoconstrictive and was produced by microglia/macrophages, our data provide what we believe to be a novel link between these cell types and vascular dysfunction in glaucoma.
Title: Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

X59556 (e-PCR)
- UniSTS:159277

Edn2 (e-PCR), detects polymorphism
- UniSTS:142961

Edn2 (e-PCR), detects polymorphism
- UniSTS:265707

Edn2 (e-PCR), detects polymorphism
- UniSTS:265457

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endothelin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables endothelin B receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cell tip growth	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle rupture	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by endothelin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by endothelin	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculature development	IDA Inferred from Direct Assay more info	PubMed
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vein smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in vein smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelin-2

Names: preproendothelin-2; vasoactive intestinal contractor peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.