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Ednra endothelin receptor type A [ Mus musculus (house mouse) ]

Gene ID: 13617, updated on 19-Jul-2021

Summary

Official Symbol
Ednraprovided by MGI
Official Full Name
endothelin receptor type Aprovided by MGI
Primary source
MGI:MGI:105923
See related
Ensembl:ENSMUSG00000031616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ET; ET-; ETa; AEA0; Gpcr; ET-AR; Mhdaa; AEA001; Gpcr10; Mhdaaea1
Expression
Broad expression in lung adult (RPKM 16.9), limb E14.5 (RPKM 15.1) and 25 other tissues See more
Orthologs
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Genomic context

See Ednra in Genome Data Viewer
Location:
8; 8 C1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (78389658..78451081, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (77663029..77724452, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (80186928..80248351, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700092C02 gene Neighboring gene predicted gene, 39200 Neighboring gene RIKEN cDNA 4933431K23 gene Neighboring gene RIKEN cDNA 4933431K23 gene Neighboring gene VISTA enhancer mm761 Neighboring gene uncharacterized LOC108167319 Neighboring gene predicted gene, 39201 Neighboring gene predicted gene, 29845

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables endothelin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endothelin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in artery smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in enteric nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histamine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of odontogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to morphine ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endothelin-1 receptor
Names
ET-A
G-protein coupled receptor 10
endothelin A receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010332.2NP_034462.1  endothelin-1 receptor precursor

    See identical proteins and their annotated locations for NP_034462.1

    Status: VALIDATED

    Source sequence(s)
    AK043210, AV351599, CN669253
    Consensus CDS
    CCDS22427.1
    UniProtKB/Swiss-Prot
    Q61614
    Related
    ENSMUSP00000034029.8, ENSMUST00000034029.8
    Conserved Domains (1) summary
    pfam00001
    Location:97367
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    78389658..78451081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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