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Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 13666, updated on 20-Jul-2021

Summary

Official Symbol
Eif2ak3provided by MGI
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 3provided by MGI
Primary source
MGI:MGI:1341830
See related
Ensembl:ENSMUSG00000031668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PE; Pek; Perk
Summary
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 10.8), colon adult (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

See Eif2ak3 in Genome Data Viewer
Location:
6; 6 C1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (70821468..70882225)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (70844484..70905241)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (70794521..70855234)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribose 5-phosphate isomerase A Neighboring gene predicted gene, 30331 Neighboring gene predicted gene, 23346 Neighboring gene testis expressed 37 Neighboring gene forkhead box I3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables eukaryotic initiation factor eIF2 binding IC
Inferred by Curator
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
 
involved_in PERK-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within SREBP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cold ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chondrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of translation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translation in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutathione biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum quality control compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 2-alpha kinase 3
Names
PRKR-like endoplasmic reticulum kinase
pancreatic eIF2-alpha kinase
NP_001300847.1
NP_034251.2
XP_006505564.1
XP_011239504.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313918.1NP_001300847.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple alternate 3' exons and uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC156398, AK010397
    Consensus CDS
    CCDS85063.1
    UniProtKB/Swiss-Prot
    Q9Z2B5
    UniProtKB/TrEMBL
    A0A0R4J1Y1
    Related
    ENSMUSP00000123759.2, ENSMUST00000162950.2
    Conserved Domains (1) summary
    cl14874
    Location:100127
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
  2. NM_010121.3NP_034251.2  eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC155842, BC054809, BP762515
    Consensus CDS
    CCDS20223.1
    UniProtKB/TrEMBL
    E9QQ30, Q7TQC8
    Related
    ENSMUSP00000034093.9, ENSMUST00000034093.15
    Conserved Domains (4) summary
    cd09768
    Location:100416
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    smart00220
    Location:8791071
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14048
    Location:8741073
    STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
    cl21453
    Location:583671
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    70821468..70882225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241202.3XP_011239504.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1

    Conserved Domains (3) summary
    cd09768
    Location:100416
    Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
    cd14048
    Location:8731072
    STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
    cl21453
    Location:582670
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006505501.2XP_006505564.1  eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2

    Conserved Domains (3) summary
    cd14048
    Location:637836
    STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
    cl14874
    Location:28179
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
    cl21453
    Location:346434
    PKc_like; Protein Kinases, catalytic domain
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