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Eln elastin [ Mus musculus (house mouse) ]

Gene ID: 13717, updated on 13-Jun-2021

Summary

Official Symbol
Elnprovided by MGI
Official Full Name
elastinprovided by MGI
Primary source
MGI:MGI:95317
See related
Ensembl:ENSMUSG00000029675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI385707; AI480567; E030024M20Rik
Summary
This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]
Expression
Broad expression in lung adult (RPKM 131.3), limb E14.5 (RPKM 72.1) and 17 other tissues See more
Orthologs
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Genomic context

See Eln in Genome Data Viewer
Location:
5 G2; 5 74.76 cM
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134731449..134776300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134702595..134747368, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135178466..135223124, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene LIM-domain containing, protein kinase Neighboring gene predicted gene 10369 Neighboring gene predicted gene, 30003 Neighboring gene transmembrane protein 270 Neighboring gene claudin 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007925.4NP_031951.2  elastin precursor

    See identical proteins and their annotated locations for NP_031951.2

    Status: REVIEWED

    Source sequence(s)
    AA183434, AC091250, AK041860
    Consensus CDS
    CCDS19725.1
    UniProtKB/Swiss-Prot
    P54320
    Related
    ENSMUSP00000015138.10, ENSMUST00000015138.13

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134731449..134776300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240855.3XP_011239157.1  elastin isoform X1

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