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Eno2 enolase 2, gamma neuronal [ Mus musculus (house mouse) ]

Gene ID: 13807, updated on 21-Apr-2024

Summary

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Official Symbol
Eno2provided by MGI
Official Full Name
enolase 2, gamma neuronalprovided by MGI
Primary source
MGI:MGI:95394
See related
Ensembl:ENSMUSG00000004267 AllianceGenome:MGI:95394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSE; Eno-2; D6Ertd375e
Summary
Predicted to enable enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Predicted to be involved in canonical glycolysis; gluconeogenesis; and negative regulation of neuron death. Located in cytoplasm; perikaryon; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 147.0), frontal lobe adult (RPKM 120.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F2; 6 59.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124737018..124746489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124760053..124769673, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8991 Neighboring gene U7 small nuclear RNA Neighboring gene atrophin 1 Neighboring gene STARR-seq mESC enhancer starr_17303 Neighboring gene leucine rich repeat containing 23 Neighboring gene predicted gene, 38895 Neighboring gene predicted gene, 38894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Sakamoto M, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21536899, Free PMC Article
  2. Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells. Levy YS, et al. J Mol Neurosci, 2003. PMID 14593212
  3. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development. Gao L, et al. J Exp Clin Cancer Res, 2023 Jan 2. PMID 36588153, Free PMC Article
  4. miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase. Xu C, et al. Mol Med Rep, 2019 Aug. PMID 31257504, Free PMC Article
  5. New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Kaneko N, et al. Sci Adv, 2018 Dec. PMID 30547091, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development.
    Title: Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development.
  2. miR153 promoted neural differentiation and protected neural cells by upregulating the neuron markers gammaenolase, neuronal nuclei, and the functional proteins SNAP23, SNAP25 and PRX5.
    Title: miR‑153 promotes neural differentiation in the mouse hippocampal HT‑22 cell line and increases the expression of neuron‑specific enolase.
  3. Study analyzed the regions that regulate the promoter strength and cellular specificity of the 1.8 kb rNSE promoter in the cerebellum in vivo. The rNSE promoter was divided into three regions (A, B, and C). Our results showed that region C was indispensable for the promoter activity in mouse cerebellum and served as an interneuron-predominant basal promoter.
    Title: Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.
  4. Plaque-associated microglial cells express gamma-enolase and cathepsin X.
    Title: Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.
  5. Treadmill exercise training decreased the expression of NSN in the striatum of chronic Parkinsonian mice, which can partially explain the beneficial neuroprotective role of exercise in patients with parkinson disease.
    Title: Effect of endurance exercise training on the expression of GFAP, S100B, and NSE in the striatum of chronic/progressive mouse model of Parkinson's disease.
  6. we induced differentiation of mouse stromal cells to neuron-like cells and observed the activation of tissue-specific promoter of neuron-specific enolase in transgenic mice with the human bcl-2 gene expressed only in neurons under the NSE promoter
    Title: Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (11) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
neural enolase
neuron-specific enolase
NP_001289571.1
NP_001342149.1
NP_001396615.1
NP_001396616.1
NP_001396617.1
NP_001396618.1
NP_001396619.1
NP_038537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302642.2 → NP_001289571.1  gamma-enolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. Variants 2, 7, and 8 all encode the same isoform (2).
    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS80609.1
    UniProtKB/TrEMBL
    D3Z6E4, Q922A0
    Related
    ENSMUSP00000108095.2, ENSMUST00000112476.8
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 313
    PLN00191; enolase

  2. NM_001355220.2 → NP_001342149.1  gamma-enolase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-6 all encode the same isoform (1).
    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS20527.1
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q3UJ20, Q545V3
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase

  3. NM_001409686.1 → NP_001396615.1  gamma-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3

  4. NM_001409687.1 → NP_001396616.1  gamma-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3

  5. NM_001409688.1 → NP_001396617.1  gamma-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3

  6. NM_001409689.1 → NP_001396618.1  gamma-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/TrEMBL
    D3Z6E4

  7. NM_001409690.1 → NP_001396619.1  gamma-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/TrEMBL
    D3Z6E4

  8. NM_013509.4 → NP_038537.1  gamma-enolase isoform 1

    See identical proteins and their annotated locations for NP_038537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3-6 all encode the same isoform (1).
    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS20527.1
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q3UJ20, Q545V3
    Related
    ENSMUSP00000004378.9, ENSMUST00000004378.15
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase

RNA

  1. NR_176885.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

  2. NR_176886.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

  3. NR_176887.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

  4. NR_176888.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

  5. NR_176889.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

  6. NR_176890.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124737018..124746489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17183.2 GenPept UniProtKB/Swiss-Prot:P17183

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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