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Epha4 Eph receptor A4 [ Mus musculus (house mouse) ]

Gene ID: 13838, updated on 12-Aug-2019

Summary

Official Symbol
Epha4provided by MGI
Official Full Name
Eph receptor A4provided by MGI
Primary source
MGI:MGI:98277
See related
Ensembl:ENSMUSG00000026235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rb; Sek; Cek8; Hek8; Sek1; Tyro1; AI385584; 2900005C20Rik
Expression
Biased expression in cortex adult (RPKM 17.3), whole brain E14.5 (RPKM 14.7) and 13 other tissues See more
Orthologs

Genomic context

See Epha4 in Genome Data Viewer
Location:
1 C4; 1 39.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (77367182..77515107, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (77363760..77511663, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene transcription factor Dp 1, pseudogene Neighboring gene Epha4 upstream enhancer in rhombomeres Neighboring gene enhancer upstream of Epha4 Neighboring gene microRNA 6352 Neighboring gene predicted gene, 32793

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DH domain binding ISO
Inferred from Sequence Orthology
more info
 
GPI-linked ephrin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
PH domain binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
corticospinal tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
fasciculation of motor neuron axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
fasciculation of sensory neuron axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell migration ISO
Inferred from Sequence Orthology
more info
 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteolysis involved in cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
nephric duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron projection fasciculation IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection guidance IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rho guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of modification of synaptic structure IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
synapse pruning EXP
Inferred from Experiment
more info
PubMed 
synapse pruning IDA
Inferred from Direct Assay
more info
PubMed 
synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse pruning ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
filopodium ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephrin type-A receptor 4
Names
tyrosine-protein kinase receptor MPK-3
tyrosine-protein kinase receptor SEK-1
NP_031962.2
XP_006496470.1
XP_006496471.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007936.3NP_031962.2  ephrin type-A receptor 4 precursor

    See identical proteins and their annotated locations for NP_031962.2

    Status: VALIDATED

    Source sequence(s)
    AC164875, AK147698, X65138
    Consensus CDS
    CCDS35627.1
    UniProtKB/Swiss-Prot
    Q03137
    Related
    ENSMUSP00000027451.6, ENSMUST00000027451.12
    Conserved Domains (7) summary
    cd09545
    Location:911981
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:915975
    SAM; Sterile alpha motif
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    77367182..77515107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496407.3XP_006496470.1  ephrin type-A receptor 4 isoform X1

    Conserved Domains (6) summary
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl15755
    Location:911949
    SAM_superfamily; SAM (Sterile alpha motif )
  2. XM_006496408.2XP_006496471.1  ephrin type-A receptor 4 isoform X2

    Conserved Domains (7) summary
    cd09545
    Location:860930
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:864924
    SAM; Sterile alpha motif
    cd10473
    Location:3152
    EphR_LBD_A; Ligand Binding Domain of Ephrin type-A Receptors
    cd00063
    Location:390481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:565831
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:570827
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:511565
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
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