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PNCK pregnancy up-regulated nonubiquitous CaM kinase [ Homo sapiens (human) ]

Gene ID: 139728, updated on 3-Apr-2024

Summary

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Official Symbol
PNCKprovided by HGNC
Official Full Name
pregnancy up-regulated nonubiquitous CaM kinaseprovided by HGNC
Primary source
HGNC:HGNC:13415
See related
Ensembl:ENSG00000130822 MIM:300680; AllianceGenome:HGNC:13415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSTK3; CaMK1b
Summary
PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 7.4), prostate (RPKM 4.6) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
Xq28
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153669733..153687771, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151943398..151961436, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152935188..152953226, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152932733-152933234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152933235-152933734 Neighboring gene RNA, 7SL, cytoplasmic 687, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21068 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152936222-152936477 Neighboring gene solute carrier family 6 member 8 Neighboring gene B cell receptor associated protein 31 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152972381-152972881 Neighboring gene Sharpr-MPRA regulatory region 5891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21070

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma. Cho YA, et al. Cancer Genomics Proteomics, 2020 Nov-Dec. PMID 33099476, Free PMC Article
  2. Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process. Deb TB, et al. Breast Cancer Res Treat, 2015 Apr. PMID 25773930
  3. Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma. Wu S, et al. PLoS One, 2013. PMID 23634203, Free PMC Article
  4. Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation. Deb TB, et al. Am J Physiol Cell Physiol, 2008 Aug. PMID 18562482, Free PMC Article
  5. The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer. Gardner HP, et al. Cancer Res, 2000 Oct 1. PMID 11034105

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.
    Title: Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.
  2. Pnck may be a marker of Trastuzumab resistance and possibly a therapeutic target in breast cancer.
    Title: Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.
  3. the relationship between PNCK and prognosis in clear cell renal cell carcinoma
    Title: Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.
  4. Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck.
    Title: Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.
  5. Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis.
    Title: Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ50403, FLJ50549, FLJ56451, FLJ59811, MGC45419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1B
Names
caM kinase I beta
caM kinase IB
caM-KI beta
caMKI-beta
pregnancy up-regulated non-ubiquitously-expressed CaM kinase
pregnancy upregulated non-ubiquitously expressed CaM kinase
NP_001034671.3
NP_001129212.1
NP_001353904.1
NP_001353905.1
NP_001353906.1
NP_001353907.1
NP_001353908.1
NP_001353909.1
XP_011529409.2
XP_011529410.1
XP_011529413.1
XP_011529414.1
XP_016884768.1
XP_024308108.1
XP_047297792.1
XP_047297793.1
XP_047297794.1
XP_047297795.1
XP_047297796.1
XP_054182469.1
XP_054182470.1
XP_054182471.1
XP_054182472.1
XP_054182473.1
XP_054182474.1
XP_054182475.1
XP_054182476.1
XP_054182477.1
XP_054182478.1
XP_054182479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039582.3 → NP_001034671.3  calcium/calmodulin-dependent protein kinase type 1B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK296203, AK303746, CF890832, DC383841
    Consensus CDS
    CCDS35503.2
    UniProtKB/Swiss-Prot
    Q6P2M8
    Related
    ENSP00000405950.2, ENST00000447676.6
    Conserved Domains (2) summary
    smart00220
    Location:98 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:94 → 370
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  2. NM_001135740.2 → NP_001129212.1  calcium/calmodulin-dependent protein kinase type 1B isoform b

    See identical proteins and their annotated locations for NP_001129212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK303746, CF890832
    Consensus CDS
    CCDS48189.1
    UniProtKB/Swiss-Prot
    Q6P2M8
    Related
    ENSP00000359164.4, ENST00000370145.8
    Conserved Domains (2) summary
    smart00220
    Location:32 → 287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:28 → 304
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  3. NM_001366975.1 → NP_001353904.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4-8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  4. NM_001366976.1 → NP_001353905.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5-8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  5. NM_001366977.1 → NP_001353906.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 6, 7, and 8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Related
    ENSP00000340586.4, ENST00000340888.8
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  6. NM_001366978.1 → NP_001353907.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 3-5, 7, and 8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  7. NM_001366979.1 → NP_001353908.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 3-6 and 8, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  8. NM_001366980.1 → NP_001353909.1  calcium/calmodulin-dependent protein kinase type 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 3-7, encodes isoform c.
    Source sequence(s)
    U52111
    Consensus CDS
    CCDS94698.1
    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Related
    ENSP00000359169.1, ENST00000370150.5
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    153669733..153687771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531107.3 → XP_011529409.2  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  2. XM_047441836.1 → XP_047297792.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  3. XM_047441838.1 → XP_047297794.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  4. XM_047441837.1 → XP_047297793.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Related
    ENST00000466074.5

  5. XM_047441839.1 → XP_047297795.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  6. XM_024452340.2 → XP_024308108.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  7. XM_011531108.3 → XP_011529410.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

    See identical proteins and their annotated locations for XP_011529410.1

    Conserved Domains (2) summary
    smart00220
    Location:33 → 288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14169
    Location:29 → 305
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  8. XM_011531112.3 → XP_011529414.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_011529414.1

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Related
    ENSP00000359161.1, ENST00000370142.5
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  9. XM_011531111.3 → XP_011529413.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    See identical proteins and their annotated locations for XP_011529413.1

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  10. XM_017029279.2 → XP_016884768.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0
    Conserved Domains (1) summary
    cd14169
    Location:11 → 287
    STKc_CaMKI_beta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta

  11. XM_047441840.1 → XP_047297796.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

    UniProtKB/TrEMBL
    B4DJP1
    Related
    ENST00000489536.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    151943398..151961436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326503.1 → XP_054182478.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  2. XM_054326496.1 → XP_054182471.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  3. XM_054326499.1 → XP_054182474.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  4. XM_054326498.1 → XP_054182473.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  5. XM_054326501.1 → XP_054182476.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  6. XM_054326497.1 → XP_054182472.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  7. XM_054326494.1 → XP_054182469.1  calcium/calmodulin-dependent protein kinase type 1B isoform X1

  8. XM_054326500.1 → XP_054182475.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  9. XM_054326495.1 → XP_054182470.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  10. XM_054326502.1 → XP_054182477.1  calcium/calmodulin-dependent protein kinase type 1B isoform X2

    UniProtKB/Swiss-Prot
    B4DJR8, B4E1A6, B7WPG0, D3DWU7, Q6P2M8, Q8N4R0

  11. XM_054326504.1 → XP_054182479.1  calcium/calmodulin-dependent protein kinase type 1B isoform X3

    UniProtKB/TrEMBL
    B4DJP1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198452.1: Suppressed sequence

    Description
    NM_198452.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P2M8.2 GenPept UniProtKB/Swiss-Prot:Q6P2M8

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