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Ac-lef3 late expression factor 3 [ Autographa californica nucleopolyhedrovirus ]

Gene ID: 1403900, updated on 18-Aug-2023

Summary

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Gene symbol
Ac-lef3
Gene description
late expression factor 3
Locus tag
ACNVgp068
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Autographa californica nucleopolyhedrovirus
Lineage
Viruses; dsDNA viruses, no RNA stage; Baculoviridae; Alphabaculovirus
Also known as
AcOrf-67
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Genomic context

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Location:
clone: C6
Sequence:
NC_001623.1 (57721..58878, complement)

NC_001623.1Genomic Context describing neighboring genes Neighboring gene DNA-dependant DNA-polymerase Neighboring gene AcOrf-66 peptide Neighboring gene AcOrf-68 peptide Neighboring gene putative methyl transferase Neighboring gene AcOrf-70 peptide

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001623.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of protein-protein interaction domains within the baculovirus Autographa californica multiple nucleopolyhedrovirus late expression factor LEF-3. Downie K, et al. J Gen Virol, 2013 Nov. PMID 23997180
  2. Identification of a domain of the baculovirus Autographa californica multiple nucleopolyhedrovirus single-strand DNA-binding protein LEF-3 essential for viral DNA replication. Yu M, et al. J Virol, 2010 Jun. PMID 20357098, Free PMC Article
  3. Analysis of the autographa californica multiple nucleopolyhedrovirus overlapping gene pair lef3 and ac68 reveals that AC68 is a per os infectivity factor and that LEF3 is critical, but not essential, for virus replication. Nie Y, et al. J Virol, 2012 Apr. PMID 22278232, Free PMC Article
  4. The complete DNA sequence of Autographa californica nuclear polyhedrosis virus. Ayres MD, et al. Virology, 1994 Aug 1. PMID 8030224

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LEF-3-LEF-3 interactions were characterized with a bimolecular fluorescent protein complementation assay.
    Title: Characterization of protein-protein interaction domains within the baculovirus Autographa californica multiple nucleopolyhedrovirus late expression factor LEF-3.
  2. LEF3 is not strictly essential for viral DNA replication or for nuclear transport of viral P143 to the nucleus.
    Title: Analysis of the autographa californica multiple nucleopolyhedrovirus overlapping gene pair lef3 and ac68 reveals that AC68 is a per os infectivity factor and that LEF3 is critical, but not essential, for virus replication.
  3. Amino acids 1 to 125od LEF-3 was sufficient to stimulate viral DNA replication and to support late gene expression.
    Title: Identification of a domain of the baculovirus Autographa californica multiple nucleopolyhedrovirus single-strand DNA-binding protein LEF-3 essential for viral DNA replication.
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General gene information

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Homology

General protein information

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Preferred Names
late expression factor 3
NP_054097.1
  • 44551 Da primary translation product

VOG classification

Description:

  • VOGd0402 [T] Nucleopolyhedrovirus late expression factor 3
  • RNA Replication, Transcription and Modification

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001623.1 Reference assembly

    Range
    57721..58878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_054097.1 late expression factor 3 [Autographa californica nucleopolyhedrovirus]

    See identical proteins and their annotated locations for NP_054097.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P41453
    UniProtKB/TrEMBL
    A0A097PUW1, A0A0N7CNC6
    Conserved Domains (1) summary
    pfam05847
    Location:22 → 385
    Baculo_LEF-3; Nucleopolyhedrovirus late expression factor 3 (LEF-3)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41453.1

Gene LinkOut

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Molecular Biology Databases