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Hnmt histamine N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 140483, updated on 11-Apr-2024

Summary

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Official Symbol
Hnmtprovided by MGI
Official Full Name
histamine N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:2153181
See related
Ensembl:ENSMUSG00000026986 AllianceGenome:MGI:2153181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500031F01Rik
Summary
Enables N-methyltransferase activity. Predicted to be involved in histamine catabolic process and methylation. Predicted to act upstream of or within regulation of neurotransmitter levels. Predicted to be located in several cellular components, including centrosome; neuron projection; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive non-syndromic intellectual disability; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 4.2), cortex adult (RPKM 3.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 16.06 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23892923..23939756, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24002911..24049758, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2D 3 pseudogene Neighboring gene speckle-type BTB/POZ protein-like Neighboring gene STARR-positive B cell enhancer mm9_chr2:23427670-23427971 Neighboring gene STARR-seq mESC enhancer starr_03932 Neighboring gene SH3 domain protein 2C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03933 Neighboring gene STARR-seq mESC enhancer starr_03934 Neighboring gene STARR-seq mESC enhancer starr_03935 Neighboring gene STARR-seq mESC enhancer starr_03936 Neighboring gene STARR-seq mESC enhancer starr_03937 Neighboring gene STARR-seq mESC enhancer starr_03939 Neighboring gene STARR-seq mESC enhancer starr_03940 Neighboring gene STARR-seq mESC enhancer starr_03942 Neighboring gene STARR-seq mESC enhancer starr_03943 Neighboring gene STARR-seq mESC enhancer starr_03944 Neighboring gene TATA box binding protein like 2 Neighboring gene STARR-seq mESC enhancer starr_03945 Neighboring gene STARR-seq mESC enhancer starr_03946 Neighboring gene interleukin 36B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice. Otsuka R, et al. Neuropharmacology, 2022 Jul 1. PMID 35487272
  2. Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Naganuma F, et al. Sci Rep, 2017 Nov 21. PMID 29162912, Free PMC Article
  3. Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice. Furukawa F, et al. Autoimmun Rev, 2009 May. PMID 19162242
  4. Genomic structure of the rat and mouse histamine N-methyltransferase gene. Kitanaka N, et al. Jpn J Pharmacol, 2002 Jan. PMID 11855681
  5. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. Preuss CV, et al. Mol Pharmacol, 1998 Apr. PMID 9547362

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity.
    Title: Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity.
  2. KO mice exhibited high aggressive behaviours and exhibited prolonged bouts of awakening during the light (inactive) period and compensatory sleep during the dark (active) period.
    Title: Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
  3. decreasing expression over the time course of the skin pathological changes in MRL/lpr mice
    Title: Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice.
  4. Genomic structure of the rat and mouse histamine N-methyltransferase gene
    Title: Genomic structure of the rat and mouse histamine N-methyltransferase gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histamine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in histamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in histamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histamine N-methyltransferase
Names
HMT
NP_536710.1
XP_006497733.1
XP_006497734.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080462.2 → NP_536710.1  histamine N-methyltransferase

    See identical proteins and their annotated locations for NP_536710.1

    Status: VALIDATED

    Source sequence(s)
    AF297037, AK160131, AW456742
    Consensus CDS
    CCDS15731.1
    UniProtKB/Swiss-Prot
    Q3TVH0, Q91VF2
    UniProtKB/TrEMBL
    A2AQK4
    Related
    ENSMUSP00000062747.6, ENSMUST00000051416.12
    Conserved Domains (1) summary
    pfam13489
    Location:32 → 218
    Methyltransf_23; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    23892923..23939756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497670.4 → XP_006497733.1  histamine N-methyltransferase isoform X1

    Conserved Domains (1) summary
    pfam13489
    Location:44 → 230
    Methyltransf_23; Methyltransferase domain

  2. XM_006497671.5 → XP_006497734.1  histamine N-methyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006497734.1

    UniProtKB/Swiss-Prot
    Q3TVH0, Q91VF2
    UniProtKB/TrEMBL
    A2AQK4
    Related
    ENSMUSP00000110142.2, ENSMUST00000114498.8
    Conserved Domains (1) summary
    pfam13489
    Location:32 → 218
    Methyltransf_23; Methyltransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VF2.1 GenPept UniProtKB/Swiss-Prot:Q91VF2

Gene LinkOut

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