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Eya2 EYA transcriptional coactivator and phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 14049, updated on 21-Apr-2024

Summary

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Official Symbol
Eya2provided by MGI
Official Full Name
EYA transcriptional coactivator and phosphatase 2provided by MGI
Primary source
MGI:MGI:109341
See related
Ensembl:ENSMUSG00000017897 AllianceGenome:MGI:109341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eab1
Summary
This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Broad expression in ovary adult (RPKM 28.8), lung adult (RPKM 23.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 85.83 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165436892..165613645)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165595028..165771727)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transformation related protein 53 regulating kinase A Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10 Neighboring gene predicted gene, 29993 Neighboring gene STARR-seq mESC enhancer starr_06353 Neighboring gene STARR-positive B cell enhancer ABC_E4519 Neighboring gene STARR-seq mESC enhancer starr_06355 Neighboring gene zinc finger, MYND-type containing 8 Neighboring gene STARR-seq mESC enhancer starr_06364 Neighboring gene RIKEN cDNA 1810021M19 gene Neighboring gene STARR-positive B cell enhancer ABC_E4520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165711164-165711317 Neighboring gene STARR-positive B cell enhancer ABC_E647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165715911-165716111 Neighboring gene predicted gene 11465

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss. Zhang T, et al. Dev Dyn, 2021 Oct. PMID 33715274, Free PMC Article
  2. Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. Maharjan BD, et al. Int J Oncol, 2019 Mar. PMID 30628662
  3. The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling. Lee SH, et al. J Mol Cell Cardiol, 2009 Apr. PMID 19272299
  4. Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. Lee SH, et al. J Mol Cell Cardiol, 2012 Mar. PMID 22197309
  5. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Xu PX, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342347, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss.
    Title: Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss.
  2. Immunoglobulin enhancerbinding factor/hepatic leukemia factor oncogenic fusion protein (E2AHLF) enhances the EYA transcriptional coactivator and phosphatase 2 (Eya2) expression by binding to the promoter region containing the E2AHLFbinding consensus sequence. Eya2 knockdown in E2AHLFimmortalized cells resulted in reduced colonyforming efficiency.
    Title: Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells.
  3. Eya2 in a physical complex with Six1 plays a critical role in physiological hypertrophy.
    Title: Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy.
  4. Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt/mTOR signaling pathway.
    Title: The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling.
  5. Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo
    Title: Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitochondrial outer membrane permeabilization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within striated muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eyes absent homolog 2
Names
eyes absent 2 homolog
NP_001258891.1
NP_001258892.1
NP_034295.1
XP_006498802.1
XP_036014160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271962.2 → NP_001258891.1  eyes absent homolog 2

    See identical proteins and their annotated locations for NP_001258891.1

    Status: VALIDATED

    Source sequence(s)
    AL591712, AL591805
    Consensus CDS
    CCDS17084.1
    UniProtKB/Swiss-Prot
    A2A5S4, O08575, P97925
    UniProtKB/TrEMBL
    Q3UV00
    Conserved Domains (2) summary
    PTZ00395
    Location:54 → 262
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:261 → 532
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  2. NM_001271963.2 → NP_001258892.1  eyes absent homolog 2

    See identical proteins and their annotated locations for NP_001258892.1

    Status: VALIDATED

    Source sequence(s)
    AL591712, AL591805
    Consensus CDS
    CCDS17084.1
    UniProtKB/Swiss-Prot
    A2A5S4, O08575, P97925
    UniProtKB/TrEMBL
    Q3UV00
    Related
    ENSMUSP00000085455.7, ENSMUST00000088132.13
    Conserved Domains (2) summary
    PTZ00395
    Location:54 → 262
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:261 → 532
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  3. NM_010165.4 → NP_034295.1  eyes absent homolog 2

    See identical proteins and their annotated locations for NP_034295.1

    Status: VALIDATED

    Source sequence(s)
    AL591712
    Consensus CDS
    CCDS17084.1
    UniProtKB/Swiss-Prot
    A2A5S4, O08575, P97925
    UniProtKB/TrEMBL
    Q3UV00
    Related
    ENSMUSP00000066244.8, ENSMUST00000063433.8
    Conserved Domains (2) summary
    PTZ00395
    Location:54 → 262
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:261 → 532
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165436892..165613645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158267.1 → XP_036014160.1  eyes absent homolog 2 isoform X1

    UniProtKB/TrEMBL
    Q3UV00, Q811N7
    Conserved Domains (2) summary
    PTZ00395
    Location:54 → 262
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:261 → 502
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

  2. XM_006498739.4 → XP_006498802.1  eyes absent homolog 2 isoform X2

    UniProtKB/TrEMBL
    Q3UV00
    Conserved Domains (2) summary
    PTZ00395
    Location:2 → 203
    PTZ00395; Sec24-related protein; Provisional
    cd02601
    Location:202 → 473
    HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08575.1 GenPept UniProtKB/Swiss-Prot:O08575

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