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Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Mus musculus (house mouse) ]

Gene ID: 140500, updated on 5-Mar-2024

Summary

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Official Symbol
Acap3provided by MGI
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by MGI
Primary source
MGI:MGI:2153589
See related
Ensembl:ENSMUSG00000029033 AllianceGenome:MGI:2153589
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Centb5; mKIAA1716; Kiaa1716-hp
Summary
Enables GTPase activator activity. Acts upstream of or within neuron migration and regulation of neuron projection development. Located in growth cone. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and spleen. Orthologous to human ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 26.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 87.66 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155976332..155991708)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155891875..155907251)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene STARR-positive B cell enhancer ABC_E9250 Neighboring gene STARR-seq mESC enhancer starr_12276 Neighboring gene pseudouridylate synthase-like 1 Neighboring gene sodium channel, nonvoltage-gated 1, delta Neighboring gene STARR-positive B cell enhancer ABC_E10298 Neighboring gene STARR-seq mESC enhancer starr_12277 Neighboring gene ubiquitin-conjugating enzyme E2J 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [CENTB5 gene expression in human and mouse]. Shubina DM, et al. Mol Biol (Mosk), 2009 May-Jun. PMID 19548526
  2. ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex. Miura Y, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28919417
  3. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119
  4. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACAP3 is involved in neuronal migration in the developing cerebral cortex of mice. Knockdown of ACAP3 in the developing cortical neurons of mice in utero significantly abrogated neuronal migration in the cortical layer, which was restored by ectopic expression of wild type of ACAP3, but not by its GTPase-activating protein - inactive mutant.
    Title: ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex.
  2. cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 in concert with a guanine-nucleotide-exchange factor(s), seems to be required for neurite outgrowth of hippocampal neurons
    Title: ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.
  3. minisatellite locus UPS29 can regulate an activity of CENTB5, SCNN1D and ACOT7 in nervous system cells.
    Title: [CENTB5 gene expression in human and mouse].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Names
centaurin, beta 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207223.1 → NP_997106.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

    See identical proteins and their annotated locations for NP_997106.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067016
    Consensus CDS
    CCDS38997.1
    UniProtKB/TrEMBL
    Q3UH98, Q6NXL5
    Related
    ENSMUSP00000101209.4, ENSMUST00000105584.10
    Conserved Domains (7) summary
    cd07637
    Location:16 → 215
    BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
    cd00204
    Location:671 → 786
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:271 → 367
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:269 → 363
    PH; PH domain
    pfam01412
    Location:403 → 521
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:671 → 764
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:700 → 731
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155976332..155991708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538541.5 → XP_006538604.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006538604.1

    UniProtKB/TrEMBL
    Q3UH98
    Related
    ENSMUST00000137726.8
    Conserved Domains (5) summary
    PTZ00322
    Location:663 → 758
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd13250
    Location:229 → 325
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:658 → 689
    ANK; ANK repeat [structural motif]
    cd08850
    Location:361 → 476
    ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)
    cl12013
    Location:1 → 173
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_006538542.3 → XP_006538605.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006538605.1

    UniProtKB/TrEMBL
    Q3UH98
    Conserved Domains (5) summary
    PTZ00322
    Location:663 → 758
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd13250
    Location:229 → 325
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:658 → 689
    ANK; ANK repeat [structural motif]
    cd08850
    Location:361 → 476
    ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)
    cl12013
    Location:1 → 173
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version

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