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Elmo2 engulfment and cell motility 2 [ Mus musculus (house mouse) ]

Gene ID: 140579, updated on 5-Mar-2024

Summary

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Official Symbol
Elmo2provided by MGI
Official Full Name
engulfment and cell motility 2provided by MGI
Primary source
MGI:MGI:2153045
See related
Ensembl:ENSMUSG00000017670 AllianceGenome:MGI:2153045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CED-12; 1190002F24Rik
Summary
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in actin filament organization and cell chemotaxis. Predicted to act upstream of or within apoptotic process and phagocytosis. Predicted to be located in cytosol and membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; nervous system; and retina. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 32.9), frontal lobe adult (RPKM 28.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Elmo2 in Genome Data Viewer
Location:
2 H3; 2 85.53 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165129951..165168421, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165288031..165326479, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25569 Neighboring gene solute carrier family 35, member C2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene zinc finger protein 663 Neighboring gene predicted gene, 29831 Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene zinc finger protein 334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ClipR-59 interacts with Elmo2 and modulates myoblast fusion. Sun Y, et al. J Biol Chem, 2015 Mar 6. PMID 25572395, Free PMC Article
  2. An ELMO2-RhoG-ILK network modulates microtubule dynamics. Jackson BC, et al. Mol Biol Cell, 2015 Jul 15. PMID 25995380, Free PMC Article
  3. Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Ho E, et al. Mol Biol Cell, 2009 Jul. PMID 19439446, Free PMC Article
  4. Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain. Katoh H, et al. Brain Res, 2006 Feb 16. PMID 16443196
  5. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Weng Z, et al. Nat Commun, 2019 Jan 3. PMID 30604775, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrated that an evolutionarily conserved fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. The crystal structures of ELMO2-RAE and its complex with BAI1 uncover the molecular basis of BAI/ELMO interactions.
    Title: Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds.
  2. Ilk and ELMO2 modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions.
    Title: Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes.
  3. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization.
    Title: Elmo2 Is a Regulator of Insulin-dependent Glut4 Membrane Translocation.
  4. ELMO2-RhoG-ILK complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
    Title: An ELMO2-RhoG-ILK network modulates microtubule dynamics.
  5. Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
    Title: ClipR-59 interacts with Elmo2 and modulates myoblast fusion.
  6. Resutls show that the interaction with ELMO2 and RhoG is essential for the ability of ILK to induce front-rear cell polarity.
    Title: Integrin-linked kinase interactions with ELMO2 modulate cell polarity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA1834

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
engulfment and cell motility protein 2
Names
CED-12 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302752.1 → NP_001289681.1  engulfment and cell motility protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001289681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK035710, AK038455, AW049501
    Consensus CDS
    CCDS17075.1
    UniProtKB/Swiss-Prot
    Q8BHL5
    Related
    ENSMUSP00000099380.3, ENSMUST00000103091.9
    Conserved Domains (3) summary
    cd13359
    Location:539 → 668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:295 → 474
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 271
    DUF3361; Domain of unknown function (DUF3361)

  2. NM_001302754.1 → NP_001289683.1  engulfment and cell motility protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001289683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the coding region compared to variant 2. It encodes isoform 4, which is shorter than isoform 2.
    Source sequence(s)
    AK033918, AK035710, AK038455, AW049501
    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:537 → 666
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:295 → 467
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 269
    DUF3361; Domain of unknown function (DUF3361)

  3. NM_080287.2 → NP_525026.2  engulfment and cell motility protein 2 isoform 3

    See identical proteins and their annotated locations for NP_525026.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AI666775, AK035710, AK045428, BC033418
    Consensus CDS
    CCDS17075.1
    UniProtKB/Swiss-Prot
    Q8BHL5
    Related
    ENSMUSP00000091887.5, ENSMUST00000094329.11
    Conserved Domains (3) summary
    cd13359
    Location:539 → 668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:295 → 474
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 271
    DUF3361; Domain of unknown function (DUF3361)

  4. NM_207706.1 → NP_997589.1  engulfment and cell motility protein 2 isoform 2

    See identical proteins and their annotated locations for NP_997589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AI666775, AK032033, AK035710, AK045428
    Consensus CDS
    CCDS17076.1
    UniProtKB/Swiss-Prot
    A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
    Related
    ENSMUSP00000073691.7, ENSMUST00000074046.13
    Conserved Domains (3) summary
    cd13359
    Location:551 → 680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:308 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 283
    DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165129951..165168421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158276.1 → XP_036014169.1  engulfment and cell motility protein 2 isoform X3

    Conserved Domains (3) summary
    cd13359
    Location:522 → 651
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:278 → 457
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 252
    DUF3361; Domain of unknown function (DUF3361)

  2. XM_036158272.1 → XP_036014165.1  engulfment and cell motility protein 2 isoform X2

    Conserved Domains (3) summary
    cd13359
    Location:539 → 668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:295 → 474
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 271
    DUF3361; Domain of unknown function (DUF3361)

  3. XM_017315487.2 → XP_017170976.1  engulfment and cell motility protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
    Conserved Domains (3) summary
    cd13359
    Location:551 → 680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:308 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 283
    DUF3361; Domain of unknown function (DUF3361)

  4. XM_011239284.2 → XP_011237586.1  engulfment and cell motility protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011237586.1

    UniProtKB/Swiss-Prot
    A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
    Conserved Domains (3) summary
    cd13359
    Location:551 → 680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:308 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 283
    DUF3361; Domain of unknown function (DUF3361)

  5. XM_011239285.2 → XP_011237587.1  engulfment and cell motility protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011237587.1

    UniProtKB/Swiss-Prot
    A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
    Conserved Domains (3) summary
    cd13359
    Location:551 → 680
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:308 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 283
    DUF3361; Domain of unknown function (DUF3361)

  6. XM_011239286.4 → XP_011237588.1  engulfment and cell motility protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011237588.1

    UniProtKB/Swiss-Prot
    Q8BHL5
    Conserved Domains (3) summary
    cd13359
    Location:539 → 668
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:295 → 474
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 271
    DUF3361; Domain of unknown function (DUF3361)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207704.1: Suppressed sequence

    Description
    NM_207704.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_207705.1: Suppressed sequence

    Description
    NM_207705.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHL5.1 GenPept UniProtKB/Swiss-Prot:Q8BHL5

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