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Sfxn1 sideroflexin 1 [ Mus musculus (house mouse) ]

Gene ID: 14057, updated on 21-Apr-2024

Summary

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Official Symbol
Sfxn1provided by MGI
Official Full Name
sideroflexin 1provided by MGI
Primary source
MGI:MGI:2137677
See related
Ensembl:ENSMUSG00000021474 AllianceGenome:MGI:2137677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810002O05Rik; A930015P12Rik
Summary
Predicted to enable D-serine transmembrane transporter activity and L-serine transmembrane transporter activity. Acts upstream of or within erythrocyte differentiation and iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human SFXN1 (sideroflexin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 32.7), large intestine adult (RPKM 19.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 28.4 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54225675..54262365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54071656..54108346)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34557 Neighboring gene dopamine receptor D1 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 34640

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Flexed Tail in the Mouse, Mus Musculus. Hunt HR, et al. Genetics, 1933 Jul. PMID 17246696, Free PMC Article
  2. Assessment of the flexed-tail mouse as a possible model for Fanconi anemia: analysis of mitomycin C-induced micronuclei. Urlando C, et al. Mutat Res, 1996 Sep 13. PMID 8879267
  3. Enzymatic studies of the hemopoietic defect in flexed mice. Coleman DL, et al. Genetics, 1969 Mar. PMID 5393940, Free PMC Article
  4. Haemopoietic progenitor cells in prenatal congenitally anaemic 'flexed-tailed' (f/f) mice. Cole RJ, et al. Br J Haematol, 1976 Jul. PMID 1276083
  5. Activities of haem synthetic enzymes in blood cells of pre-natal flexed-tailed (f/f) anaemic mice. Cole RJ, et al. J Embryol Exp Morphol, 1975 Oct. PMID 1194836

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-serine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-alanine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-serine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within iron ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within iron ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of one-carbon metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in serine import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serine import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sideroflexin-1
Names
flexed tail

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428618.1 → NP_001415547.1  sideroflexin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176
    UniProtKB/Swiss-Prot
    Q3UB44, Q99JR1, Q9CZG4

  2. NM_001428619.1 → NP_001415548.1  sideroflexin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176
    UniProtKB/Swiss-Prot
    Q3UB44, Q99JR1, Q9CZG4

  3. NM_001428620.1 → NP_001415549.1  sideroflexin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176
    UniProtKB/Swiss-Prot
    Q3UB44, Q99JR1, Q9CZG4

  4. NM_001428621.1 → NP_001415550.1  sideroflexin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  5. NM_001428622.1 → NP_001415551.1  sideroflexin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  6. NM_001428624.1 → NP_001415553.1  sideroflexin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  7. NM_001428625.1 → NP_001415554.1  sideroflexin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  8. NM_001428626.1 → NP_001415555.1  sideroflexin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  9. NM_027324.6 → NP_081600.1  sideroflexin-1 isoform 1

    See identical proteins and their annotated locations for NP_081600.1

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176
    Consensus CDS
    CCDS26525.1
    UniProtKB/Swiss-Prot
    Q3UB44, Q99JR1, Q9CZG4
    Related
    ENSMUSP00000021930.9, ENSMUST00000021930.10
    Conserved Domains (1) summary
    pfam03820
    Location:16 → 322
    Mtc; Tricarboxylate carrier

RNA

  1. NR_190428.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  2. NR_190429.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  3. NR_190430.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  4. NR_190431.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  5. NR_190432.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  6. NR_190433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

  7. NR_190434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163343, CT030176

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54225675..54262365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516849.5 → XP_006516912.2  sideroflexin-1 isoform X1

    Conserved Domains (1) summary
    pfam03820
    Location:16 → 322
    Mtc; Tricarboxylate carrier

  2. XM_006516850.5 → XP_006516913.1  sideroflexin-1 isoform X1

    Conserved Domains (1) summary
    pfam03820
    Location:16 → 322
    Mtc; Tricarboxylate carrier

RNA

  1. XR_003950425.1 RNA Sequence

  2. XR_004937937.1 RNA Sequence

  3. XR_003950424.2 RNA Sequence

  4. XR_004937936.1 RNA Sequence

  5. XR_004937939.1 RNA Sequence

  6. XR_004937938.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JR1.3 GenPept UniProtKB/Swiss-Prot:Q99JR1

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