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Atp5me ATP synthase membrane subunit e [ Rattus norvegicus (Norway rat) ]

Gene ID: 140608, updated on 5-Mar-2024

Summary

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Official Symbol
Atp5meprovided by RGD
Official Full Name
ATP synthase membrane subunit eprovided by RGD
Primary source
RGD:621377
See related
AllianceGenome:RGD:621377
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp5i; Atp5k
Summary
Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP metabolic process. Located in mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5ME (ATP synthase membrane subunit e). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 6476.4), Muscle (RPKM 4205.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1464788..1465989)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1319868..1320996)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2325308..2326436)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 3 Neighboring gene solute carrier family 49 member 3 Neighboring gene phosphodiesterase 6B Neighboring gene uncharacterized LOC134481810 Neighboring gene uncharacterized LOC102556249

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Complete amino acid sequence of subunit e of rat liver mitochondrial H(+)-ATP synthase. Higuti T, et al. Biochemistry, 1992 Dec 15. PMID 1463732
  2. A simple, rapid method for purification of epsilon-subunit, coupling factor 6, subunit d, and subunit e from rat liver H(+)-ATP synthase and determination of the complete amino acid sequence of epsilon-subunit. Higuti T, et al. J Biol Chem, 1992 Nov 5. PMID 1429613
  3. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, et al. J Biol Chem, 2000 Oct 20. PMID 10887193
  4. Identification of two proteins associated with mammalian ATP synthase. Meyer B, et al. Mol Cell Proteomics, 2007 Oct. PMID 17575325
  5. A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies. Aggeler R, et al. J Biol Chem, 2002 Sep 13. PMID 12110673

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP5me alleviates high glucose-induced myocardial cell injury.
    Title: ATP5me alleviates high glucose-induced myocardial cell injury.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP synthase subunit e, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E
ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATPase subunit e
NP_536729.1
XP_063128881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080481.1 → NP_536729.1  ATP synthase subunit e, mitochondrial

    See identical proteins and their annotated locations for NP_536729.1

    Status: PROVISIONAL

    Source sequence(s)
    D13121
    UniProtKB/Swiss-Prot
    P29419
    UniProtKB/TrEMBL
    A6KPF6
    Conserved Domains (1) summary
    pfam05680
    Location:2 → 35
    ATP-synt_E; ATP synthase E chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    1464788..1465989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272811.1 → XP_063128881.1  ATP synthase subunit e, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29419.3 GenPept UniProtKB/Swiss-Prot:P29419

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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