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Ap2b1 adaptor related protein complex 2 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140670, updated on 30-Sep-2021

Summary

Symbol
Ap2b1provided by RGD
Full Name
adaptor related protein complex 2 subunit beta 1provided by RGD
Primary source
RGD:71048
See related
EnsemblRapid:ENSRNOG00000061543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
subunit of the clathrin-associated protein complex 2 [RGD, Feb 2006]
Expression
Biased expression in Testes (RPKM 391.0), Brain (RPKM 322.3) and 9 other tissues See more
Orthologs
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Genomic context

See Ap2b1 in Genome Data Viewer
Location:
10q26
Exon count:
25
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68099397..68205023)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70516462..70621973)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095157 Neighboring gene 40S ribosomal protein S27-like Neighboring gene Z30 small nucleolar RNA Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac septum development ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin coat assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AP-type membrane coat adaptor complex TAS
Traceable Author Statement
more info
PubMed 
part_of clathrin adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AP-2 complex subunit beta
Names
AP-1 complex subunit beta-1-like
AP-2 complex subunit beta-like
AP105B
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
adaptor protein complex AP-2 subunit beta
adaptor-related protein complex 2 subunit beta
adaptor-related protein complex 2, beta 1 subunit
beta-2-adaptin
beta-adaptin
beta2-adaptin
clathrin assembly protein complex 2 beta large chain
plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080583.2NP_542150.1  AP-2 complex subunit beta

    See identical proteins and their annotated locations for NP_542150.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Related
    ENSRNOP00000070905.1, ENSRNOT00000088198.2
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    68099397..68205023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767937.3XP_008766159.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766159.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  2. XM_017596973.2XP_017452462.1  AP-2 complex subunit beta isoform X1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  3. XM_008767936.3XP_008766158.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766158.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  4. XM_008767938.2XP_008766160.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766160.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Related
    ENSRNOP00000073619.2, ENSRNOT00000090446.2
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  5. XM_008767939.3XP_008766161.1  AP-2 complex subunit beta isoform X2

    See identical proteins and their annotated locations for XP_008766161.1

    UniProtKB/Swiss-Prot
    P62944
    Related
    ENSRNOP00000084537.1, ENSRNOT00000117903.1
    Conserved Domains (4) summary
    smart00809
    Location:717817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  6. XM_008767935.3XP_008766157.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766157.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
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