Format

Send to:

Choose Destination

Fbn2 fibrillin 2 [ Mus musculus (house mouse) ]

Gene ID: 14119, updated on 20-Jul-2021

Summary

Official Symbol
Fbn2provided by MGI
Official Full Name
fibrillin 2provided by MGI
Primary source
MGI:MGI:95490
See related
Ensembl:ENSMUSG00000024598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
s; sy; sne; Fib-; Fib-2; BC063774; mKIAA4226
Expression
Biased expression in limb E14.5 (RPKM 40.9), CNS E11.5 (RPKM 13.1) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fbn2 in Genome Data Viewer
Location:
18 D3; 18 32.15 cM
Exon count:
66
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (58141689..58343200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (58008623..58210572, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (58168277..58369580, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35751 Neighboring gene solute carrier family 12, member 2 Neighboring gene predicted gene, 41741 Neighboring gene predicted gene, 54032

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4226

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in microfibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in microfibril ISO
Inferred from Sequence Orthology
more info
 
located_in microfibril TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
fibrillin-2
Names
syndatyly ems

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010181.2NP_034311.2  fibrillin-2 precursor

    See identical proteins and their annotated locations for NP_034311.2

    Status: VALIDATED

    Source sequence(s)
    AC102317, AC127358
    Consensus CDS
    CCDS37827.1
    UniProtKB/Swiss-Prot
    Q61555
    Related
    ENSMUSP00000025497.6, ENSMUST00000025497.8
    Conserved Domains (9) summary
    cd11304
    Location:28212868
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00179
    Location:22062245
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:803838
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00683
    Location:17421779
    TB; TB domain
    pfam06247
    Location:12861439
    Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
    pfam12662
    Location:783806
    cEGF; Complement Clr-like EGF-like
    pfam12947
    Location:14051440
    EGF_3; EGF domain
    pfam14670
    Location:12391274
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:24822522
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    58141689..58343200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317828.3XP_017173317.1  fibrillin-2 isoform X1

    Conserved Domains (10) summary
    cd11304
    Location:27882835
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00179
    Location:21732212
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:770805
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00683
    Location:9711013
    TB; TB domain
    pfam12662
    Location:750773
    cEGF; Complement Clr-like EGF-like
    pfam12947
    Location:13721407
    EGF_3; EGF domain
    pfam14670
    Location:12061241
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    pfam18193
    Location:76112
    Fibrillin_U_N; Fibrillin 1 unique N-terminal domain
    cl00057
    Location:24872523
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl21504
    Location:285325
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_030250333.2XP_030106193.1  fibrillin-2 isoform X2

    Conserved Domains (8) summary
    cd11304
    Location:22032250
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00179
    Location:15881627
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:185220
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00683
    Location:386428
    TB; TB domain
    pfam12662
    Location:165188
    cEGF; Complement Clr-like EGF-like
    pfam12947
    Location:787822
    EGF_3; EGF domain
    pfam14670
    Location:621656
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:19021938
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Support Center