Fgf3 fibroblast growth factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf3provided by MGI
Official Full Name: fibroblast growth factor 3provided by MGI
Primary source: MGI:MGI:95517
See related: Ensembl:ENSMUSG00000031074 AllianceGenome:MGI:95517
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf-3; Fgf5c; Int-2; Int-P
Summary: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including inner ear morphogenesis; post-anal tail morphogenesis; and thymus development. Located in Golgi apparatus. Is expressed in several structures, including brain; branchial arch; egg cylinder; jaw; and sensory organ. Orthologous to human FGF3 (fibroblast growth factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 2.4), CNS E14 (RPKM 2.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.85 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (144392349..144397085)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (144838612..144843348)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.
Title: The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.
Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival.
Title: Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival.
results indicate that Fgf3 hypomethylation and gene overexpression, but not protein expression, occurred in the early stage of oral carcinogenesis induced by DBP
Title: Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene.
We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist.
Title: An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.
FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing beta-catenin signaling.
Title: FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.
Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.
Title: Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.
Data suggest that Fgf3/Fgfr3 signaling is required for maintenance of Gnrh (gonadotropin-releasing hormone) neurons in aging hypothalamus; postnatal Gnrh system is plastic/resilient, able to override preexisting defects and respond to external cues.
Title: Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency.
Fgf3 and Fgf10 are not required for specification of cardiovascular progenitors, but rather for their normal developmental coordination.
Title: Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Microarray analysis was used to identify prospective placode genes that were differently expressed in control and Fgf3(-)(/)(-)embryos.
Title: FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
alterations in dosage of the Fgf3 gene cause dental morphological changes in genetically engineered mutants
Title: Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgf3 (e-PCR), detects polymorphism
- UniSTS:507926

Fgf3 (e-PCR), detects polymorphism
- UniSTS:273721

D7Nds4 (e-PCR), detects polymorphism
- UniSTS:142694

Y00848 (e-PCR)
- UniSTS:163433

Fgf3 (e-PCR), detects polymorphism
- UniSTS:464784

Y00848 (e-PCR)
- UniSTS:186281

NoName (e-PCR)
- UniSTS:491229

Fgf3 (e-PCR), detects polymorphism
- UniSTS:258269

Fgf3 (e-PCR), detects polymorphism
- UniSTS:143090

Fgf3 (e-PCR), detects polymorphism
- UniSTS:143091

Fgf3 (e-PCR), detects polymorphism
- UniSTS:143092

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ induction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic vesicle formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in otic vesicle formation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within semicircular canal morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor 3

Names: HBGF-3; INT-2 proto-oncogene protein; fibroblast growth factor 5c; heparin-binding growth factor 3; proto-oncogene Int-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.