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Fgfr1 fibroblast growth factor receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14182, updated on 28-Nov-2021

Summary

Official Symbol
Fgfr1provided by MGI
Official Full Name
fibroblast growth factor receptor 1provided by MGI
Primary source
MGI:MGI:95522
See related
Ensembl:ENSMUSG00000031565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLG; Fr1; MFR; Eask; Hspy; Flt-2; c-fgr; FGFR-I; Fgfr-1; AW208770; bFGF-R-1
Expression
Broad expression in limb E14.5 (RPKM 38.2), adrenal adult (RPKM 35.4) and 23 other tissues See more
Orthologs
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Genomic context

See Fgfr1 in Genome Data Viewer
Location:
8 A2; 8 14.12 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26008775..26065734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25518759..25575718)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (26629244..26686186)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10689 Neighboring gene predicted gene, 31045 Neighboring gene Fgfr1 promoter region Neighboring gene predicted gene, 31288 Neighboring gene VISTA enhancer mm612 Neighboring gene predicted gene 16159 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 2 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene predicted gene, 24992

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor-receptor interaction ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cementum mineralization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cementum mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in diphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in diphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within generation of neurons IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motogenic signaling involved in postnatal olfactory bulb interneuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in orbitofrontal cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within outer ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic cell cycle DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of parathyroid hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of lateral mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of phosphate transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of phosphorus metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to sodium phosphate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to sodium phosphate IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular zone neuroblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vitamin D3 metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor receptor 1
Names
basic fibroblast growth factor receptor 1
proto-oncogene c-Fgr
NP_001073377.1
NP_001073378.1
NP_034336.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079908.2NP_001073377.1  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001073377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI480534, AK028354, AK034295, AK049704, BU611199, CF532036
    Consensus CDS
    CCDS57614.1
    UniProtKB/Swiss-Prot
    P16092
    UniProtKB/TrEMBL
    Q8CBY7, Q8CIM9
    Related
    ENSMUSP00000113909.3, ENSMUST00000117179.9
    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001079909.2NP_001073378.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001073378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI480534, AK028354, AK034295, AK049704, BU611199, CF532036
    Consensus CDS
    CCDS40304.1
    UniProtKB/Swiss-Prot
    P16092
    UniProtKB/TrEMBL
    Q8CBY7
    Related
    ENSMUSP00000113855.3, ENSMUST00000119398.10
    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_010206.3NP_034336.2  fibroblast growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034336.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI480534, AK028354, AK034295, AK049704, BU611199, CF532036
    Consensus CDS
    CCDS52526.1
    UniProtKB/Swiss-Prot
    P16092
    UniProtKB/TrEMBL
    Q8CBY7
    Related
    ENSMUSP00000081041.6, ENSMUST00000084027.13
    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26008775..26065734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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