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Fgfr4 fibroblast growth factor receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 14186, updated on 2-Aug-2021

Summary

Official Symbol
Fgfr4provided by MGI
Official Full Name
fibroblast growth factor receptor 4provided by MGI
Primary source
MGI:MGI:95525
See related
Ensembl:ENSMUSG00000005320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fgfr-; Fgfr-4
Expression
Biased expression in adrenal adult (RPKM 26.0), lung adult (RPKM 20.3) and 14 other tissues See more
Orthologs
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Genomic context

See Fgfr4 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55300631..55316572)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55152818..55168759)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55254179..55270120)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene nuclear receptor-binding SET-domain protein 1 Neighboring gene RAB24, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within alveolar secondary septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within organ induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of parathyroid hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of bile acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of bile acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of phosphate transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of phosphorus metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vitamin D3 metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibroblast growth factor receptor 4
Names
CTLA-2-beta protein
fibroblast growth factor receptor 4 16 minus form
protein-tyrosine kinase receptor MPK-11
NP_032037.2
XP_006517162.3
XP_006517163.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008011.2NP_032037.2  fibroblast growth factor receptor 4 precursor

    See identical proteins and their annotated locations for NP_032037.2

    Status: VALIDATED

    Source sequence(s)
    AK084850
    Consensus CDS
    CCDS26540.1
    UniProtKB/Swiss-Prot
    Q03142
    UniProtKB/TrEMBL
    A0A0R4IZY3
    Related
    ENSMUSP00000005452.6, ENSMUST00000005452.6
    Conserved Domains (6) summary
    cd05099
    Location:451764
    PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
    cd05858
    Location:261348
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:47104
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:159238
    IG_like; Immunoglobulin like
    pfam07714
    Location:464740
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:154238
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55300631..55316572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517099.3XP_006517162.3  fibroblast growth factor receptor 4 isoform X1

    Conserved Domains (4) summary
    cd05099
    Location:481794
    PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
    cd05858
    Location:291378
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:77134
    IGc2; Immunoglobulin C-2 Type
    cl11960
    Location:184268
    Ig; Immunoglobulin domain
  2. XM_006517100.2XP_006517163.1  fibroblast growth factor receptor 4 isoform X2

    Conserved Domains (2) summary
    cd05099
    Location:205518
    PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
    cd05858
    Location:15102
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
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