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Fhl1 four and a half LIM domains 1 [ Mus musculus (house mouse) ]

Gene ID: 14199, updated on 16-Oct-2021

Summary

Official Symbol
Fhl1provided by MGI
Official Full Name
four and a half LIM domains 1provided by MGI
Primary source
MGI:MGI:1298387
See related
Ensembl:ENSMUSG00000023092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KyoT; SLIM; FHL-1; SLIM-1; RAM14-1
Expression
Broad expression in bladder adult (RPKM 335.4), lung adult (RPKM 134.7) and 17 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Fhl1 in Genome Data Viewer
Location:
X; X A6
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55776569..55838706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56731209..56793346)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (53984964..54046523)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36289 Neighboring gene predicted gene, 26312 Neighboring gene predicted gene, 23258 Neighboring gene MAP7 domain containing 3 Neighboring gene adhesion G protein-coupled receptor G4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
four and a half LIM domains protein 1
Names
RBP-associated molecule 14-1
skeletal muscle LIM-protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077361.1NP_001070829.1  four and a half LIM domains protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001070829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK158966, AL671998
    Consensus CDS
    CCDS40981.1
    UniProtKB/TrEMBL
    A2AEY2
    Related
    ENSMUSP00000110417.3, ENSMUST00000114769.9
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001077362.2NP_001070830.1  four and a half LIM domains protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001070830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL671998
    Consensus CDS
    CCDS40980.1
    UniProtKB/Swiss-Prot
    P97447
    UniProtKB/TrEMBL
    A2AEX8
    Related
    ENSMUSP00000110420.3, ENSMUST00000114772.9
    Conserved Domains (5) summary
    cd09344
    Location:56109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:233296
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:117174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:178230
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:2149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. NM_001287800.1NP_001274729.1  four and a half LIM domains protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001274729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the use of an alternate promoter, differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 3, also known as KyoT1) has a distinct C-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AL671998
    Consensus CDS
    CCDS30148.1
    UniProtKB/Swiss-Prot
    P97447
    Related
    ENSMUSP00000110421.4, ENSMUST00000114773.10
    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. NM_010211.3NP_034341.2  four and a half LIM domains protein 1 isoform 3

    See identical proteins and their annotated locations for NP_034341.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 3, also known as KyoT1) has a distinct C-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AL671998
    Consensus CDS
    CCDS30148.1
    UniProtKB/Swiss-Prot
    P97447
    Related
    ENSMUSP00000023854.4, ENSMUST00000023854.10
    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    55776569..55838706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318381.3XP_017173870.1  four and a half LIM domains protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P97447
    Related
    ENSMUSP00000112295.2, ENSMUST00000116596.8
    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_006527803.2XP_006527866.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527866.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_030251223.2XP_030107083.1  four and a half LIM domains protein 1 isoform X3

    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. XM_036161815.1XP_036017708.1  four and a half LIM domains protein 1 isoform X5

    Conserved Domains (3) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. XM_006527802.3XP_006527865.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527865.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  6. XM_030251224.2XP_030107084.1  four and a half LIM domains protein 1 isoform X4

    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  7. XM_030251225.2XP_030107085.1  four and a half LIM domains protein 1 isoform X5

    Conserved Domains (3) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  8. XM_017318382.2XP_017173871.1  four and a half LIM domains protein 1 isoform X5

    UniProtKB/Swiss-Prot
    P97447
    Conserved Domains (3) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  9. XM_006527801.2XP_006527864.1  four and a half LIM domains protein 1 isoform X2

    Conserved Domains (4) summary
    cd09344
    Location:56109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:117174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:178230
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:2149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  10. XM_006527809.3XP_006527872.1  four and a half LIM domains protein 1 isoform X6

    UniProtKB/TrEMBL
    A2AEX7
    Related
    ENSMUSP00000110416.4, ENSMUST00000114768.10
    Conserved Domains (3) summary
    cd09344
    Location:56109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:117174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:2149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  11. XM_006527805.3XP_006527868.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527868.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  12. XM_006527800.4XP_006527863.2  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527863.2

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  13. XM_006527808.3XP_006527871.2  four and a half LIM domains protein 1 isoform X5

    UniProtKB/Swiss-Prot
    P97447
    Conserved Domains (3) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  14. XM_006527807.2XP_006527870.2  four and a half LIM domains protein 1 isoform X4

    Related
    ENSMUSP00000116725.2, ENSMUST00000144600.8
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  15. XM_006527804.2XP_006527867.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527867.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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