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Fkbp7 FK506 binding protein 7 [ Mus musculus (house mouse) ]

Gene ID: 14231, updated on 23-Jun-2021

Summary

Official Symbol
Fkbp7provided by MGI
Official Full Name
FK506 binding protein 7provided by MGI
Primary source
MGI:MGI:1336879
See related
Ensembl:ENSMUSG00000002732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
23kDa; FKBP2; FKBP-7; FKBP23
Expression
Broad expression in bladder adult (RPKM 28.4), limb E14.5 (RPKM 18.1) and 15 other tissues See more
Orthologs
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Genomic context

See Fkbp7 in Genome Data Viewer
Location:
2 C3; 2 45.09 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76493378..76503442, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76663034..76673098, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (76501091..76511155, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator Neighboring gene pejvakin Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 Neighboring gene predicted gene, 39860 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP7
Names
23 kDa FK506-binding protein
23 kDa FKBP
FKBP-23
PPIase FKBP7
rotamase
NP_001342008.1
NP_001342009.1
NP_034352.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355079.1NP_001342008.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AI182368, AL928867
    Conserved Domains (2) summary
    pfam00254
    Location:42136
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:147209
    EF-hand_7; EF-hand domain pair
  2. NM_001355080.1NP_001342009.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL928867
    Conserved Domains (2) summary
    pfam13499
    Location:40102
    EF-hand_7; EF-hand domain pair
    cl19519
    Location:1229
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
  3. NM_010222.2NP_034352.1  peptidyl-prolyl cis-trans isomerase FKBP7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (1).
    Source sequence(s)
    AL928867
    Consensus CDS
    CCDS16161.1
    UniProtKB/Swiss-Prot
    O54998
    UniProtKB/TrEMBL
    Q3UU11
    Related
    ENSMUSP00000002809.8, ENSMUST00000002809.14
    Conserved Domains (3) summary
    pfam00254
    Location:42137
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:148210
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:148209
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    76493378..76503442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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