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Fn1 fibronectin 1 [ Mus musculus (house mouse) ]

Gene ID: 14268, updated on 25-Nov-2021

Summary

Official Symbol
Fn1provided by MGI
Official Full Name
fibronectin 1provided by MGI
Primary source
MGI:MGI:95566
See related
Ensembl:ENSMUSG00000026193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fn; Fn-1; E330027I09
Expression
Broad expression in placenta adult (RPKM 211.5), liver E18 (RPKM 196.6) and 22 other tissues See more
Orthologs
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Genomic context

See Fn1 in Genome Data Viewer
Location:
1 C3; 1 36.05 cM
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (71624632..71692439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (71585473..71653280, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (71632097..71699745, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6947 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene apolipoprotein L 7d Neighboring gene PRP4 pre-mRNA processing factor 4 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117493

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables mercury ion binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proteoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proteoglycan binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in biological process involved in interaction with symbiont ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcium-independent cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-substrate junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mercury ion ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin activation ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration involved in autonomic nervous system development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276408.1NP_001263337.1  fibronectin isoform b precursor

    See identical proteins and their annotated locations for NP_001263337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147249, AK147683, CJ098561, CJ099024, CN534124
    Consensus CDS
    CCDS78612.1
    UniProtKB/TrEMBL
    A0A087WR50, Q3UGY5, Q3UHR1
    Related
    ENSMUSP00000140471.2, ENSMUST00000188894.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22932332
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  2. NM_001276409.1NP_001263338.1  fibronectin isoform c precursor

    See identical proteins and their annotated locations for NP_001263338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147315, CJ098561
    Consensus CDS
    CCDS78611.1
    UniProtKB/TrEMBL
    Q3UHL6
    Related
    ENSMUSP00000140975.2, ENSMUST00000187938.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22682307
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  3. NM_001276410.1NP_001263339.1  fibronectin isoform d precursor

    See identical proteins and their annotated locations for NP_001263339.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147315, AK171339, CJ098561, CK639246, CN532664, CN536551, CN692112
    Consensus CDS
    CCDS78609.1
    UniProtKB/TrEMBL
    A0A087WSN6, Q3TBB4, Q3UHL6
    Related
    ENSMUSP00000141123.2, ENSMUST00000186129.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22032242
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  4. NM_001276411.1NP_001263340.1  fibronectin isoform e precursor

    See identical proteins and their annotated locations for NP_001263340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147663, BC138421, CJ098561
    Consensus CDS
    CCDS78608.1
    UniProtKB/TrEMBL
    B9EHT6
    Related
    ENSMUSP00000140816.2, ENSMUST00000190780.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21782217
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  5. NM_001276412.1NP_001263341.1  fibronectin isoform f precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147315, AK147639, CJ098561
    Consensus CDS
    CCDS78610.1
    UniProtKB/TrEMBL
    A0A087WS56, Q3UH17, Q3UHL6
    Related
    ENSMUSP00000140907.2, ENSMUST00000188674.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21732212
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  6. NM_001276413.1NP_001263342.1  fibronectin isoform g precursor

    See identical proteins and their annotated locations for NP_001263342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147701, AK171339, CJ098561
    Consensus CDS
    CCDS78607.1
    UniProtKB/TrEMBL
    B7ZNJ1, Q3TBB4
    Related
    ENSMUSP00000139702.2, ENSMUST00000189821.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:20832122
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  7. NM_010233.2NP_034363.1  fibronectin isoform a precursor

    See identical proteins and their annotated locations for NP_034363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC124821, AK133868, CF166960, CF727068, CJ098561, CK637170, CK638401, CN460535, CN534124, CN538894, CN694596
    Consensus CDS
    CCDS15031.1
    UniProtKB/Swiss-Prot
    P11276
    UniProtKB/TrEMBL
    Q3UZF9
    Related
    ENSMUSP00000054499.7, ENSMUST00000055226.13
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23842423
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19942074
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15411620
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    71624632..71692439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315837.2XP_017171326.1  fibronectin isoform X5

    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21742213
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  2. XM_030248098.1XP_030103958.1  fibronectin isoform X3

    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22692308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  3. XM_006495699.4XP_006495762.1  fibronectin isoform X2

    See identical proteins and their annotated locations for XP_006495762.1

    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  4. XM_006495700.4XP_006495763.1  fibronectin isoform X4

    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  5. XM_006495697.4XP_006495760.1  fibronectin isoform X1

    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23592398
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
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