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Srgap2 SLIT-ROBO Rho GTPase activating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14270, updated on 19-Sep-2021

Summary

Official Symbol
Srgap2provided by MGI
Official Full Name
SLIT-ROBO Rho GTPase activating protein 2provided by MGI
Primary source
MGI:MGI:109605
See related
Ensembl:ENSMUSG00000026425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP; Fnb; FBP2; Fnbp2; srGAP3; AI448945; 9930124L22Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 9.6), CNS E18 (RPKM 8.8) and 27 other tissues See more
Orthologs
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Genomic context

See Srgap2 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131212989..131455269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131285251..131527531, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (133181828..133423938, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene bystin-like pseudogene Neighboring gene predicted gene 28913 Neighboring gene inhibitor of kappaB kinase epsilon Neighboring gene predicted gene, 51644 Neighboring gene predicted gene, 53252 Neighboring gene family with sequence similarity 72, member A Neighboring gene arginine vasopressin receptor 1B Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament severing ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in lamellipodium assembly involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SLIT-ROBO Rho GTPase-activating protein 2
Names
FBP-27
formin binding protein 2
formin-binding protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081011.2NP_001074480.2  SLIT-ROBO Rho GTPase-activating protein 2

    See identical proteins and their annotated locations for NP_001074480.2

    Status: VALIDATED

    Source sequence(s)
    AC165436, AK084412, BC030457, BY779945, CF164437
    Consensus CDS
    CCDS48355.1
    UniProtKB/Swiss-Prot
    Q91Z67
    Related
    ENSMUSP00000095195.3, ENSMUST00000097588.9
    Conserved Domains (3) summary
    cd07682
    Location:26289
    F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
    cd11955
    Location:732784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487674
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131212989..131455269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160225.1XP_036016118.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

    Related
    ENSMUSP00000139405.2, ENSMUST00000186543.7
    Conserved Domains (3) summary
    cd11955
    Location:732784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487674
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26289
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001781100.2 RNA Sequence

  2. XR_004939453.1 RNA Sequence

  3. XR_001781103.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019520.1: Suppressed sequence

    Description
    NM_019520.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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