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Brd2 bromodomain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 14312, updated on 23-Jun-2021

Summary

Official Symbol
Brd2provided by MGI
Official Full Name
bromodomain containing 2provided by MGI
Primary source
MGI:MGI:99495
See related
Ensembl:ENSMUSG00000024335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ri; Rn; Fsr; Nat; Frg-; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; AW228947; D17H6S113; mKIAA4005; D17H6S113E
Expression
Ubiquitous expression in thymus adult (RPKM 36.3), adrenal adult (RPKM 32.4) and 28 other tissues See more
Orthologs
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Genomic context

See Brd2 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34330993..34341581, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34112019..34122814, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34248964..34258692, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene histocompatibility 2, class II, locus Mb2 Neighboring gene histocompatibility 2, class II, locus Mb1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4005

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bromodomain-containing protein 2
Names
female sterile homeotic-related gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204973.1NP_001191902.1  bromodomain-containing protein 2

    See identical proteins and their annotated locations for NP_001191902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK168525, BY244178, CB527269, CO040867
    Consensus CDS
    CCDS28641.1
    UniProtKB/Swiss-Prot
    Q7JJ13
    UniProtKB/TrEMBL
    B2RS09
    Related
    ENSMUSP00000025193.7, ENSMUST00000025193.14
    Conserved Domains (4) summary
    cd05497
    Location:73179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215332
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:639701
    BET; Bromodomain extra-terminal - transcription regulation
  2. NM_010238.3NP_034368.2  bromodomain-containing protein 2

    See identical proteins and their annotated locations for NP_034368.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variant 2.
    Source sequence(s)
    AK158970, CB246848, CO040867
    Consensus CDS
    CCDS28641.1
    UniProtKB/Swiss-Prot
    Q7JJ13
    UniProtKB/TrEMBL
    B2RS09
    Related
    ENSMUSP00000109880.3, ENSMUST00000114242.9
    Conserved Domains (4) summary
    cd05497
    Location:73179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215332
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:639701
    BET; Bromodomain extra-terminal - transcription regulation

RNA

  1. NR_037970.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK147918, BC046809, BM947875
    Related
    ENSMUST00000154232.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34330993..34341581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160322.1XP_036016215.1  bromodomain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    cd05498
    Location:229330
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:96213
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:520582
    BET; Bromodomain extra-terminal - transcription regulation
    cl02556
    Location:160
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  2. XM_036160321.1XP_036016214.1  bromodomain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd05497
    Location:73179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215332
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:639701
    BET; Bromodomain extra-terminal - transcription regulation
  3. XM_030249501.1XP_030105361.1  bromodomain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    cd05498
    Location:229330
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:96213
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:520582
    BET; Bromodomain extra-terminal - transcription regulation
    cl02556
    Location:160
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  4. XM_017317255.3XP_017172744.1  bromodomain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    pfam17035
    Location:314376
    BET; Bromodomain extra-terminal - transcription regulation
    cl02556
    Location:74124
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  5. XM_036160323.1XP_036016216.1  bromodomain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    pfam17035
    Location:314376
    BET; Bromodomain extra-terminal - transcription regulation
    cl02556
    Location:74124
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  6. XM_030249500.2XP_030105360.1  bromodomain-containing protein 2 isoform X2

    Related
    ENSMUSP00000092990.8, ENSMUST00000095347.13
    Conserved Domains (4) summary
    cd05497
    Location:27133
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:302403
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:169286
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:593655
    BET; Bromodomain extra-terminal - transcription regulation
  7. XM_030249499.2XP_030105359.1  bromodomain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    cd05497
    Location:73179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    PHA03247
    Location:215332
    PHA03247; large tegument protein UL36; Provisional
    pfam17035
    Location:639701
    BET; Bromodomain extra-terminal - transcription regulation

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025387.2: Suppressed sequence

    Description
    NM_001025387.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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