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Dtx1 deltex 1, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 14357, updated on 23-Jun-2021

Summary

Official Symbol
Dtx1provided by MGI
Official Full Name
deltex 1, E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:1352744
See related
Ensembl:ENSMUSG00000029603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fxit; Fxit1; mKIAA4160
Expression
Biased expression in spleen adult (RPKM 82.7), CNS E18 (RPKM 30.0) and 14 other tissues See more
Orthologs
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Genomic context

See Dtx1 in Genome Data Viewer
Location:
5 F; 5 60.64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120818268..120849755, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120680203..120711867, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (121130273..121161678, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 54 Neighboring gene cilia and flagella associated protein 73 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene 2'-5' oligoadenylate synthetase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DTX1
Names
FXI-T1
RING-type E3 ubiquitin transferase DTX1
deltex 1 homolog
deltex1
fractionated x-irradiation induced transcript 1
mDTX1
protein deltex-1
NP_032078.2
XP_011246482.1
XP_011246483.1
XP_030109991.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008052.3NP_032078.2  E3 ubiquitin-protein ligase DTX1

    See identical proteins and their annotated locations for NP_032078.2

    Status: PROVISIONAL

    Source sequence(s)
    AK169455
    Consensus CDS
    CCDS19624.1
    UniProtKB/Swiss-Prot
    Q61010
    Related
    ENSMUSP00000031607.7, ENSMUST00000031607.7
    Conserved Domains (3) summary
    smart00678
    Location:26102
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16671
    Location:415483
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    pfam18102
    Location:486620
    DTC; Deltex C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120818268..120849755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248180.3XP_011246482.1  E3 ubiquitin-protein ligase DTX1 isoform X1

    See identical proteins and their annotated locations for XP_011246482.1

    Conserved Domains (3) summary
    smart00678
    Location:26102
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16671
    Location:415487
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    pfam18102
    Location:490624
    DTC; Deltex C-terminal domain
  2. XM_030254131.1XP_030109991.1  E3 ubiquitin-protein ligase DTX1 isoform X2

    Conserved Domains (3) summary
    smart00678
    Location:26102
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16671
    Location:415483
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    pfam18102
    Location:486620
    DTC; Deltex C-terminal domain
  3. XM_011248181.4XP_011246483.1  E3 ubiquitin-protein ligase DTX1 isoform X1

    See identical proteins and their annotated locations for XP_011246483.1

    Conserved Domains (3) summary
    smart00678
    Location:26102
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16671
    Location:415487
    RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins
    pfam18102
    Location:490624
    DTC; Deltex C-terminal domain
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