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Fzd3 frizzled class receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 14365, updated on 20-Jul-2021

Summary

Official Symbol
Fzd3provided by MGI
Official Full Name
frizzled class receptor 3provided by MGI
Primary source
MGI:MGI:108476
See related
Ensembl:ENSMUSG00000007989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fz3; AU020229; D930050A07Rik
Expression
Broad expression in whole brain E14.5 (RPKM 1.9), CNS E11.5 (RPKM 1.8) and 17 other tissues See more
Orthologs
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Genomic context

See Fzd3 in Genome Data Viewer
Location:
14 D1; 14 34.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65429890..65499912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65192441..65262463, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (65811278..65881300, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene predicted gene, 52119 Neighboring gene predicted gene, 30008 Neighboring gene predicted gene, 41177 Neighboring gene predicted gene 9086 Neighboring gene predicted gene, 52141 Neighboring gene F-box protein 16 Neighboring gene predicted gene, 41178 Neighboring gene predicted gene, 48449 Neighboring gene zinc finger protein 395

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell proliferation in midbrain IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopaminergic neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in planar cell polarity pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonergic neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in sympathetic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
colocalizes_with presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
frizzled-3
Names
frizzled homolog 3
fz-3
mFz3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021458.2NP_067433.1  frizzled-3 precursor

    See identical proteins and their annotated locations for NP_067433.1

    Status: VALIDATED

    Source sequence(s)
    AC124489, AC152169, BB664692, BC050965, U43205
    Consensus CDS
    CCDS27212.1
    UniProtKB/Swiss-Prot
    Q61086
    Related
    ENSMUSP00000115325.2, ENSMUST00000131309.3
    Conserved Domains (2) summary
    cd07449
    Location:24150
    CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
    pfam01534
    Location:193512
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65429890..65499912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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