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Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 [ Mus musculus (house mouse) ]

Gene ID: 14409, updated on 12-May-2024

Summary

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Official Symbol
Gabrr2provided by MGI
Official Full Name
gamma-aminobutyric acid type A receptor subunit rho 2provided by MGI
Primary source
MGI:MGI:95626
See related
Ensembl:ENSMUSG00000023267 AllianceGenome:MGI:95626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GABA-A receptor activity. Acts upstream of or within gamma-aminobutyric acid signaling pathway and visual perception. Predicted to be located in axon. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 14.64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33057715..33095865)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33057712..33095865)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2J 1 Neighboring gene basic transcription factor 3, pseudogene 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33159852-33160053 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 1 Neighboring gene STARR-seq mESC enhancer starr_09882 Neighboring gene peptidase M20 domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking spinal α2GABA(A) receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype. Tudeau L, et al. Brain Res, 2020 Aug 15. PMID 32439345
  2. GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex. Denter DG, et al. Neuroscience, 2010 Apr 28. PMID 20123002
  3. Cloning and characterization of mouse GABA(C) receptor subunits. Greka A, et al. Neuroreport, 1998 Jan 26. PMID 9507960
  4. Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina. McCall MA, et al. J Neurosci, 2002 May 15. PMID 12019334, Free PMC Article
  5. Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina. Wu Y, et al. Brain Res, 2001 Aug 31. PMID 11520487

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice lacking spinal alpha2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype.
    Title: Mice lacking spinal α2GABA(A) receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GABA-A receptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transport TAS
Traceable Author Statement
more info
 PubMed 
NOT acts_upstream_of_or_within eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon TAS
Traceable Author Statement
more info
 PubMed 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit rho-2
Names
GABA(A) receptor subunit rho-2
GABA(C) receptor
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2
gamma-aminobutyric acid receptor rho2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420866.1 → NP_001407795.1  gamma-aminobutyric acid receptor subunit rho-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670464

  2. NM_001420867.1 → NP_001407796.1  gamma-aminobutyric acid receptor subunit rho-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670464

  3. NM_008076.4 → NP_032102.2  gamma-aminobutyric acid receptor subunit rho-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032102.2

    Status: VALIDATED

    Source sequence(s)
    AL670464
    Consensus CDS
    CCDS18020.1
    UniProtKB/Swiss-Prot
    P56476, Q6PEP0
    Related
    ENSMUSP00000024035.3, ENSMUST00000024035.9
    Conserved Domains (3) summary
    TIGR00860
    Location:74 → 489
    LIC; Cation transporter family protein
    pfam02931
    Location:87 → 286
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:293 → 486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RNA

  1. NR_185208.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670464

  2. NR_185209.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670464

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    33057715..33095865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537616.3 → XP_006537679.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X1

    UniProtKB/Swiss-Prot
    P56476, Q6PEP0
    Conserved Domains (2) summary
    TIGR00860
    Location:15 → 430
    LIC; Cation transporter family protein
    cd19005
    Location:42 → 227
    LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho

  2. XM_036163682.1 → XP_036019575.1  gamma-aminobutyric acid receptor subunit rho-2 isoform X2

    UniProtKB/Swiss-Prot
    P56476, Q6PEP0
    Conserved Domains (2) summary
    TIGR00860
    Location:12 → 415
    LIC; Cation transporter family protein
    cd19005
    Location:27 → 212
    LGIC_ECD_GABAAR_rho; extracellular domain of gamma-aminobutyric acid receptor subunit rho
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56476.4 GenPept UniProtKB/Swiss-Prot:P56476

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