U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CSNK1A1 casein kinase 1 alpha 1 [ Homo sapiens (human) ]

Gene ID: 1452, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
CSNK1A1provided by HGNC
Official Full Name
casein kinase 1 alpha 1provided by HGNC
Primary source
HGNC:HGNC:2451
See related
Ensembl:ENSG00000113712 MIM:600505; AllianceGenome:HGNC:2451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 69.2), gall bladder (RPKM 47.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (149492982..149551439, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150027795..150086185, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148872545..148931002, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene Sharpr-MPRA regulatory region 1487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148812860-148813360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148820757-148821574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148821575-148822392 Neighboring gene Sharpr-MPRA regulatory region 14097 Neighboring gene microRNA 143 Neighboring gene microRNA 145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148837126-148837626 Neighboring gene Sharpr-MPRA regulatory region 12996 Neighboring gene uncharacterized LOC124901105 Neighboring gene NANOG hESC enhancer GRCh37_chr5:148878477-148879023 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82175 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82187 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:148920536-148920739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148924456-148925365 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148927595-148928130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:148929064-148930263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148931159-148931952 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene Rho guanine nucleotide exchange factor 37 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16498 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23379 Neighboring gene Sharpr-MPRA regulatory region 10925 Neighboring gene MPRA-validated peak5533 silencer Neighboring gene RNA, U6 small nuclear 588, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23382 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:149011522-149012721 Neighboring gene uncharacterized LOC124901104

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Casein kinase 1α mediates eryptosis: a review. Tkachenko A, et al. Apoptosis, 2023 Feb. PMID 36308624
  2. Down-Regulation of Casein Kinase 1α Contributes to Endometriosis through Phosphatase and Tensin Homolog/Autophagy-Related 7-Mediated Autophagy. Zhou A, et al. Am J Pathol, 2021 Dec. PMID 34809787
  3. Reprogramming of erythrocyte lifespan by NFκB-TNFα naphthoquinone antagonist β-lapachone is regulated by calcium overload and CK1α. Alfhili MA, et al. J Food Biochem, 2021 Apr. PMID 33749832
  4. Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication. Klann K, et al. Mol Cell, 2020 Oct 1. PMID 32877642, Free PMC Article
  5. Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein. Davidson AD, et al. Genome Med, 2020 Jul 28. PMID 32723359, Free PMC Article

See all (262) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.
    Title: Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.
  2. CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling.
    Title: CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.
  3. Selective CK1alpha degraders exert antiproliferative activity against a broad range of human cancer cell lines.
    Title: Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
  4. Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
    Title: Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
  5. Casein kinase 1alpha mediates eryptosis: a review.
    Title: Casein kinase 1α mediates eryptosis: a review.
  6. CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.
    Title: CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.
  7. Decreased Expressions of CK1alpha and PTEN in Sinonasal Inverted Papilloma.
    Title: Decreased Expressions of CK1α and PTEN in Sinonasal Inverted Papilloma.
  8. Down-Regulation of Casein Kinase 1alpha Contributes to Endometriosis through Phosphatase and Tensin Homolog/Autophagy-Related 7-Mediated Autophagy.
    Title: Down-Regulation of Casein Kinase 1α Contributes to Endometriosis through Phosphatase and Tensin Homolog/Autophagy-Related 7-Mediated Autophagy.
  9. FAM83F regulates canonical Wnt signalling through an interaction with CK1alpha.
    Title: FAM83F regulates canonical Wnt signalling through an interaction with CK1α.
  10. Reprogramming of erythrocyte lifespan by NFkappaB-TNFalpha naphthoquinone antagonist beta-lapachone is regulated by calcium overload and CK1alpha.
    Title: Reprogramming of erythrocyte lifespan by NFκB-TNFα naphthoquinone antagonist β-lapachone is regulated by calcium overload and CK1α.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Wnt signaling pathway TAS
Traceable Author Statement
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral protein processing TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
part_of beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium TAS
Traceable Author Statement
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
colocalizes_with keratin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
casein kinase I isoform alpha
Names
CKI-alpha
clock regulator kinase
down-regulated in lung cancer
epididymis secretory sperm binding protein Li 77p
NP_001020276.1
NP_001258670.1
NP_001258671.1
NP_001883.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025105.3 → NP_001020276.1  casein kinase I isoform alpha isoform 1

    See identical proteins and their annotated locations for NP_001020276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021078, BC008717, BC021971, BU618830, DA144898, DQ082865
    Consensus CDS
    CCDS47304.1
    UniProtKB/TrEMBL
    V9HW00
    Related
    ENSP00000261798.6, ENST00000261798.10
    Conserved Domains (1) summary
    cd14128
    Location:16 → 309
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  2. NM_001271741.2 → NP_001258670.1  casein kinase I isoform alpha isoform 3

    See identical proteins and their annotated locations for NP_001258670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame internal exon and uses an alternate splice site, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC021078, AF218004, BC008717, BC009186, BU618830, DA144898
    Consensus CDS
    CCDS64291.1
    UniProtKB/TrEMBL
    V9HW00
    Related
    ENSP00000499757.1, ENST00000657001.1
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

  3. NM_001271742.2 → NP_001258671.1  casein kinase I isoform alpha isoform 4

    See identical proteins and their annotated locations for NP_001258671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021078, AK293761, BC008717, BU618830, HY119498
    UniProtKB/TrEMBL
    B4DER9, B4E1D9
    Related
    ENSP00000427031.1, ENST00000515435.5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 220
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001892.6 → NP_001883.4  casein kinase I isoform alpha isoform 2

    See identical proteins and their annotated locations for NP_001883.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame internal exon, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC021078, BC008717, BC009186, BU618830, DA144898, L37042
    Consensus CDS
    CCDS47303.1
    UniProtKB/Swiss-Prot
    D3DQG0, D3DQG1, P48729, Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2, Q9UDK3
    UniProtKB/TrEMBL
    V9HW00
    Related
    ENSP00000367074.2, ENST00000377843.8
    Conserved Domains (1) summary
    cd14128
    Location:16 → 281
    STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    149492982..149551439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    150027795..150086185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48729.2 GenPept UniProtKB/Swiss-Prot:P48729

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous