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MDP1 magnesium dependent phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 145553, updated on 5-Mar-2024

Summary

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Official Symbol
MDP1provided by HGNC
Official Full Name
magnesium dependent phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:28781
See related
Ensembl:ENSG00000213920 AllianceGenome:HGNC:28781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP-1; FN6PASE
Summary
Predicted to enable acid phosphatase activity. Predicted to be involved in fructosamine metabolic process and peptidyl-tyrosine dephosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 7.9), kidney (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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See MDP1 in Genome Data Viewer
Location:
14q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24213943..24216066, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18412319..18414442, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24683149..24685272, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis specific serine kinase 4 Neighboring gene charged multivesicular body protein 4A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24682177-24682985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24683998-24684736 Neighboring gene NEDD8-MDP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8198 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24701437-24702302 Neighboring gene guanosine monophosphate reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer. Zhu J, et al. Curr Cancer Drug Targets, 2019. PMID 31218958
  2. Expression and prognostic roles of magnesium-dependent phosphatase-1 in gastric cancer. Chen Y, et al. Eur Rev Med Pharmacol Sci, 2017 Jun. PMID 28678323
  3. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. Fortpied J, et al. J Biol Chem, 2006 Jul 7. PMID 16670083
  4. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Selengut JD, et al. Biochemistry, 2000 Jul 18. PMID 10889041
  5. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CHMP4A

Readthrough NEDD8-MDP1

Readthrough gene: NEDD8-MDP1, Included gene: NEDD8

Homology

Clone Names

  • MGC5987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
magnesium-dependent phosphatase 1
Names
fructosamine-6-phosphatase
NP_001186750.1
NP_001186751.1
NP_001399117.1
NP_612485.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199821.2 → NP_001186750.1  magnesium-dependent phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_001186750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC046912, DA287183
    Consensus CDS
    CCDS55908.1
    UniProtKB/Swiss-Prot
    Q86V88
    Related
    ENSP00000380045.2, ENST00000396833.2
    Conserved Domains (1) summary
    cl21460
    Location:3 → 86
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001199822.2 → NP_001186751.1  magnesium-dependent phosphatase 1 isoform 3

    See identical proteins and their annotated locations for NP_001186751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918790, CB046258, DA287183
    Conserved Domains (1) summary
    pfam12689
    Location:3 → 135
    Acid_PPase; Acid Phosphatase

  3. NM_001412188.1 → NP_001399117.1  magnesium-dependent phosphatase 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents an alternate allele of variant 1 on T2TCHM13v2.0 assembly (rs3215610). It encodes isoform 4, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    CP068264

  4. NM_138476.4 → NP_612485.2  magnesium-dependent phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_612485.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA918790, BC051382, DA287183
    Consensus CDS
    CCDS9620.1
    UniProtKB/Swiss-Prot
    Q86V88, Q86Y84, Q8NAD9
    Related
    ENSP00000288087.7, ENST00000288087.12
    Conserved Domains (1) summary
    pfam12689
    Location:3 → 160
    Acid_PPase; Acid Phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24213943..24216066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    514921..517044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18412319..18414442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86V88.1 GenPept UniProtKB/Swiss-Prot:Q86V88

Gene LinkOut

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