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Gfi1 growth factor independent 1 transcription repressor [ Mus musculus (house mouse) ]

Gene ID: 14581, updated on 27-Jul-2021

Summary

Official Symbol
Gfi1provided by MGI
Official Full Name
growth factor independent 1 transcription repressorprovided by MGI
Primary source
MGI:MGI:103170
See related
Ensembl:ENSMUSG00000029275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P; Pa; Gfi-; Pal1; Gfi-1; Pal-1; AW495828
Expression
Biased expression in thymus adult (RPKM 40.7), colon adult (RPKM 6.0) and 3 other tissues See more
Orthologs
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Genomic context

See Gfi1 in Genome Data Viewer
Location:
5 F; 5 52.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107864521..107873671, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107716655..107725805, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108145674..108153363, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Gfi1 +35 kb enhancer Neighboring gene RIKEN cDNA 4930428O21 gene Neighboring gene +19.5 kb enhancer downstream of Gfi1 Neighboring gene Gfi1 +5.8 kb enhancer Neighboring gene Gfi1 promoter regions Neighboring gene -8.7 kb enhancer upstream of Gfi1 Neighboring gene predicted gene, 42147

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein Gfi-1
Names
growth factor independent protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267621.1NP_001254550.1  zinc finger protein Gfi-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138666, AV261275
    Consensus CDS
    CCDS59680.1
    UniProtKB/TrEMBL
    H3BJM0
    Related
    ENSMUSP00000135039.3, ENSMUST00000065478.12
    Conserved Domains (3) summary
    COG5048
    Location:321483
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:421446
    zf-H2C2_2; Zinc-finger double domain
  2. NM_010278.2NP_034408.1  zinc finger protein Gfi-1 isoform 1

    See identical proteins and their annotated locations for NP_034408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC138666, AV261275
    Consensus CDS
    CCDS57371.1
    UniProtKB/Swiss-Prot
    P70338
    UniProtKB/TrEMBL
    A0A0R4J292
    Related
    ENSMUSP00000135884.3, ENSMUST00000031205.16
    Conserved Domains (3) summary
    COG5048
    Location:255417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315335
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:355380
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    107864521..107873671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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