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E4 control protein E4 34K;control protein E4orf1;control protein E4orf2;control protein E4orf3;control protein E4orf4;control protein E4orf6/7 [ Human mastadenovirus A ]

Gene ID: 1460865, updated on 18-Aug-2023

Summary

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Gene symbol
E4
Gene description
control protein E4 34K;control protein E4orf1;control protein E4orf2;control protein E4orf3;control protein E4orf4;control protein E4orf6/7
Locus tag
HAdVAgp16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human mastadenovirus A (strain: Huie, serotype: Human adenovirus 12, acronym: HAdV-12, acronym: HAdV-A, nat-host: Homo sapiens, culture-collection: ATCC:VR-863)
Lineage
Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus
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Genomic context

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Sequence:
NC_001460.1 (31166..33843, complement)

NC_001460.1Genomic Context describing neighboring genes Neighboring gene capsid protein precursor pVIII;encapsidation protein 22K;hexon assembly protein 100K;protein 33K Neighboring gene fiber Neighboring gene control protein E3 12.5K;control protein E3 14.7K;membrane glycoprotein E3 CR1-alpha;membrane glycoprotein E3 CR1-beta;membrane protein E3 RID-alpha;membrane protein E3 RID-beta Neighboring gene protein U

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001460.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation. Kuroshima T, et al. Oncogene, 2011 Jun 30. PMID 21317928
  2. Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases. Gilson T, et al. J Virol, 2014 Apr. PMID 24453364, Free PMC Article
  3. Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis. Sprengel J, et al. J Virol, 1994 Jan. PMID 8254750, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nevertheless, the identification of the Cul2 box may allow prediction of Cullin specificity for all E4orf6-containing Adenoviridae.
    Title: Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.
  2. Stabilized ARE-mRNA is necessary, if not all, for the oncogenic activity of E4orf6 and has the potential to transform cells, at least under a certain condition.
    Title: Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation.
Submit: New GeneRIF Correction

General gene information

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Homology

regulatory

  • Loc: c31171-31166 regulatory_class = polyA_signal_sequence
  • Loc: c33843-33838 regulatory_class = TATA_box

General protein information

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Preferred Names
control protein E4 34K;control protein E4orf1;control protein E4orf2;control protein E4orf3;control protein E4orf4;control protein E4orf6/7
NP_040934.1
  • genus-specific; 34K family
NP_040935.1
  • genus-specific
NP_040936.1
  • genus-specific
NP_597784.2
  • genus-specific
YP_002640223.1
  • genus-specific
YP_002640224.1
  • genus-specific; DURP family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001460.1 Reference assembly

    Range
    31166..33843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_597784.2 control protein E4orf6/7 [Human mastadenovirus A]

    See identical proteins and their annotated locations for NP_597784.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3G8W4S6

  2. NP_040934.1 control protein E4 34K [Human mastadenovirus A]

    See identical proteins and their annotated locations for NP_040934.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36710
    UniProtKB/TrEMBL
    A0A3G8W3L7
    Conserved Domains (1) summary
    pfam04528
    Location:131 → 275
    Adeno_E4_34; Adenovirus early E4 34 kDa protein conserved region

  3. NP_040935.1 control protein E4orf4 [Human mastadenovirus A]

    See identical proteins and their annotated locations for NP_040935.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36709
    UniProtKB/TrEMBL
    A0A3G8WH22
    Conserved Domains (1) summary
    pfam05385
    Location:18 → 107
    Adeno_E4; Mastadenovirus early E4 13 kDa protein

  4. NP_040936.1 control protein E4orf3 [Human mastadenovirus A]

    See identical proteins and their annotated locations for NP_040936.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36708
    UniProtKB/TrEMBL
    D0Z5U9, D3JIU8, G1DE43, T1UE68
    Conserved Domains (1) summary
    pfam06931
    Location:4 → 116
    Adeno_E4_ORF3; Mastadenovirus E4 ORF3 protein

  5. YP_002640223.1 control protein E4orf2 [Human mastadenovirus A]

    See identical proteins and their annotated locations for YP_002640223.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3G8W5G2

  6. YP_002640224.1 control protein E4orf1 [Human mastadenovirus A]

    See identical proteins and their annotated locations for YP_002640224.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3G8WBR2
    Conserved Domains (1) summary
    cl00493
    Location:5 → 121
    trimeric_dUTPase; Trimeric dUTP diphosphatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
CAA51901.1
CAA51902.1
CAA51903.1

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