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CSRP1 cysteine and glycine rich protein 1 [ Homo sapiens (human) ]

Gene ID: 1465, updated on 7-Apr-2024

Summary

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Official Symbol
CSRP1provided by HGNC
Official Full Name
cysteine and glycine rich protein 1provided by HGNC
Primary source
HGNC:HGNC:2469
See related
Ensembl:ENSG00000159176 MIM:123876; AllianceGenome:HGNC:2469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141; HEL-S-286
Summary
This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Expression
Broad expression in prostate (RPKM 425.1), endometrium (RPKM 406.6) and 22 other tissues See more
Orthologs
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Genomic context

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See CSRP1 in Genome Data Viewer
Location:
1q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201483530..201507123, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200741308..200764907, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201452658..201476251, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201430707-201431289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201437987-201438701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2320 Neighboring gene pleckstrin homology like domain family A member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1692 Neighboring gene uncharacterized LOC124904484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201487479-201487990 Neighboring gene CSRP1 antisense RNA 1 Neighboring gene ribosomal protein S10 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201534809-201535310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201535311-201535810 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10615 Neighboring gene neuron navigator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201560646-201561209 Neighboring gene uncharacterized LOC124904482 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:201591323-201591707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201597565-201598066

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis. Yu S, et al. Genet Res (Camb), 2023. PMID 37113556, Free PMC Article
  2. Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study. Gürel E, et al. Herz, 2015 May. PMID 24357092
  3. Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis. Järvinen PM, et al. J Cell Physiol, 2012 Jun. PMID 21882188
  4. The LIM/double zinc-finger motif functions as a protein dimerization domain. Feuerstein R, et al. Proc Natl Acad Sci U S A, 1994 Oct 25. PMID 7938009, Free PMC Article
  5. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. Liebhaber SA, et al. Nucleic Acids Res, 1990 Jul 11. PMID 2115670, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis.
    Title: CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis.
  2. Plasma ADMA is a useful parameter for predicting subclinical atherosclerosis, whereas homocysteine and hsCRP are not
    Title: Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study.
  3. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
    Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
  4. Results show that CRP1 is a novel TGF-beta1 regulated protein that is expressed in fibrotic lesions and may be relevant in idiopathic pulmonary fibrosis.
    Title: Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.
  5. CRP1 expression is regulated by UVB in human keratinocytes, suggesting a role for CRP1 in the phototoxic responses of human skin.
    Title: Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Hypomethylation of wingless-related MMTV integration site 5A (WNT5A), S100 calcium-binding protein P (S100P) and cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by bisulfite sequencing.
    Title: Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer.
  8. Aberrant methylation of CSRP1 is associated with hepatocellular carcinoma
    Title: Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686M148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in platelet aggregation HMP PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysteine and glycine-rich protein 1
Names
LIM-domain protein
cysteine-rich protein 1
epididymis luminal protein 141
epididymis secretory protein Li 286
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193570.2 → NP_001180499.1  cysteine and glycine-rich protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001180499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC096677, AK302237, BC032493
    UniProtKB/TrEMBL
    B3KVC9, B4DY28
    Conserved Domains (2) summary
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)
    cl02475
    Location:119 → 166
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001193571.2 → NP_001180500.1  cysteine and glycine-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001180500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC096677, AK290133, BC032493
    Consensus CDS
    CCDS1413.1
    UniProtKB/Swiss-Prot
    A8K268, P21291, Q5U0J2
    UniProtKB/TrEMBL
    A0A384P5K2, B3KVC9
    Related
    ENSP00000436792.1, ENST00000533432.5
    Conserved Domains (2) summary
    cd09403
    Location:119 → 172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

  3. NM_001193572.2 → NP_001180501.1  cysteine and glycine-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001180501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC096677, AK293053, BC032493
    Consensus CDS
    CCDS1413.1
    UniProtKB/Swiss-Prot
    A8K268, P21291, Q5U0J2
    UniProtKB/TrEMBL
    A0A384P5K2, B3KVC9
    Related
    ENSP00000434147.1, ENST00000532460.5
    Conserved Domains (2) summary
    cd09403
    Location:119 → 172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

  4. NM_004078.3 → NP_004069.1  cysteine and glycine-rich protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AW163500, BC032493, CA411857, CF453919
    Consensus CDS
    CCDS1413.1
    UniProtKB/Swiss-Prot
    A8K268, P21291, Q5U0J2
    UniProtKB/TrEMBL
    A0A384P5K2, B3KVC9
    Related
    ENSP00000345079.2, ENST00000340006.7
    Conserved Domains (2) summary
    cd09403
    Location:119 → 172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    201483530..201507123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    200741308..200764907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001144773.1: Suppressed sequence

    Description
    NM_001144773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21291.3 GenPept UniProtKB/Swiss-Prot:P21291

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