Format

Send to:

Choose Destination

Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus [ Mus musculus (house mouse) ]

Gene ID: 14683, updated on 5-Nov-2021

Summary

Official Symbol
Gnasprovided by MGI
Official Full Name
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locusprovided by MGI
Primary source
MGI:MGI:95777
See related
Ensembl:ENSMUSG00000027523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P1; P2; P3; GSP; Gsa; POH; GPSA; Nesp; SCG6; Gnas1; Nespl; PHP1A; PHP1B; Gnasxl; Nesp55; Oedsml; Galphas; Oed-Sml; Gs-alpha; 5530400H20Rik; A930027G11Rik; C130027O20Rik
Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]
Expression
Ubiquitous expression in limb E14.5 (RPKM 151.3), cerebellum adult (RPKM 99.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gnas in Genome Data Viewer
Location:
2 H4; 2 97.89 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (174126113..174188537)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174284320..174346744)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (174109821..174172245)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 296 Neighboring gene microRNA 298 Neighboring gene GNAS antisense RNA 1 Neighboring gene predicted gene, 30189 Neighboring gene negative elongation factor complex member C/D, Th1l Neighboring gene ribosomal protein L30, pseudogene 5 Neighboring gene cathepsin Z

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118029

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D1 dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables alkylglycerophosphoethanolamine phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables corticotropin-releasing hormone receptor 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables corticotropin-releasing hormone receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mu-type opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mu-type opioid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in developmental growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within energy reserve metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair follicle placode formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of parathyroid hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to parathyroid hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of chemical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in COPI-coated Golgi to ER transport vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
PubMed 
located_in intrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
Names
Gs alpha subunit
adenylate cyclase-stimulating G alpha protein
alternative gene product encoded by XL-exon
extra large alphas protein
neuroendocrine secretory protein 55
secretogranin VI
stimulatory G-protein alpha subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077507.2NP_001070975.1  protein GNAS isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as GNASXL) is paternally expressed. It has an alternate 5' exon, lacks an internal exon and uses an alternate splice site in the coding region, compared to variant 7. It encodes isoform f (also known as XLas), which has a longer and distinct N-terminus and lacks an internal segment, compared to isoform GNASL. Isoform f is the neuroendocrine-specific G-protein alpha subunit.
    Source sequence(s)
    AF116268, AK030489, AL593857, BU516278
    Consensus CDS
    CCDS38354.1
    UniProtKB/Swiss-Prot
    Q6R0H6, Q6R0H7
    Related
    ENSMUSP00000085184.5, ENSMUST00000087876.11
    Conserved Domains (2) summary
    cd00066
    Location:7801113
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:7591116
    G_alpha; G protein alpha subunit
  2. NM_001077510.5NP_001070978.1  protein GNAS isoform GNASS

    See identical proteins and their annotated locations for NP_001070978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is biallelically expressed. It lacks an internal exon and uses an alternate splice site, compared to variant 7. It encodes the isoform GNASS, also known as alpha-S1, which lacks an internal segment and has two amino acids different, compared to isoform GNASL.
    Source sequence(s)
    AK159563, AL593857, BC062654, BU054033, DV057819
    Consensus CDS
    CCDS38357.1
    UniProtKB/Swiss-Prot
    P63094
    Related
    ENSMUSP00000104713.2, ENSMUST00000109085.8
    Conserved Domains (1) summary
    cd00066
    Location:41374
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  3. NM_001310083.1NP_001297012.1  protein GNAS isoform GNASL

    See identical proteins and their annotated locations for NP_001297012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 7. Variants 7 and 10 encode the same isoform guanine nucleotide binding protein alpha-s long (GNASL, also known as alpha-S2), a form of the G-protein alpha subunit.
    Source sequence(s)
    BC062654, BM944582, BU516278
    Consensus CDS
    CCDS38356.1
    UniProtKB/Swiss-Prot
    P63094
    Related
    ENSMUSP00000085179.5, ENSMUST00000087871.11
    Conserved Domains (1) summary
    cd00066
    Location:41388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  4. NM_001310085.1NP_001297014.1  protein GNAS isoform XXLb2

    See identical proteins and their annotated locations for NP_001297014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) is paternally expressed and includes an alternate 5' exon structure, compared to variant 7. This variant is reported in PMID:15148396. It encodes isoform XXLb2, which has a distinct and shorter C-terminus, compared to isoform XLas.
    Source sequence(s)
    AK030489, AK132636, AL593857, BU516278
    Consensus CDS
    CCDS89590.1
    UniProtKB/Swiss-Prot
    Q6R0H6, Q6R0H7
    Related
    ENSMUSP00000158758.2, ENSMUST00000154658.8
    Conserved Domains (2) summary
    smart00275
    Location:759786
    G_alpha; G protein alpha subunit
    PRK12323
    Location:330531
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
  5. NM_001364030.1NP_001350959.1  protein ALEX isoform i

    Status: REVIEWED

    Source sequence(s)
    AL593857
    Consensus CDS
    CCDS89591.1
    Related
    ENSMUSP00000104712.2, ENSMUST00000109084.8
    Conserved Domains (1) summary
    cd00066
    Location:41373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  6. NM_010309.4NP_034439.2  protein GNAS isoform XLas

    See identical proteins and their annotated locations for NP_034439.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as GNASXL) is paternally expressed. It includes an alternate 5' exon, compared to variant 7. This variant includes two overlapping open reading frames encoding distinct isoforms XLas and Alex, respectively. This RefSeq represents the isoform XLas (also known as alpha sXXL), which is a neuroendocrine-specific G-protein alpha subunit. It has a distinct and longer N-terminus, compared to isoform GNASL.
    Source sequence(s)
    AK132636, AL593857, BU516278
    Consensus CDS
    CCDS17151.1
    UniProtKB/Swiss-Prot
    Q6R0H7
    Related
    ENSMUSP00000140174.2, ENSMUST00000185956.7
    Conserved Domains (2) summary
    cd00066
    Location:7801127
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:7591130
    G_alpha; G protein alpha subunit
  7. NM_019690.3NP_062664.2  protein SCG6 (secretogranin VI) isoform SCG6 precursor

    See identical proteins and their annotated locations for NP_062664.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is maternally expressed. It lacks several 3' exons and has alternate 5' and 3' exons, compared to variant 7. Variants 3 and 4 both encode isoform secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. The coding regions of variants 3 and 4 do not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript NESPAS.
    Source sequence(s)
    AJ010163, AL593857, AV353621, BB632851, BX636499, BY600941, BY718446, CF730992
    Consensus CDS
    CCDS17149.1
    UniProtKB/Swiss-Prot
    Q9Z0F1
    Related
    ENSMUSP00000136180.2, ENSMUST00000180362.8
    Conserved Domains (1) summary
    pfam06390
    Location:1253
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
  8. NM_022000.3NP_068840.2  protein SCG6 (secretogranin VI) isoform SCG6 precursor

    See identical proteins and their annotated locations for NP_068840.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is maternally expressed and has alternate 5' exons, compared to variant 7. Variants 3 and 4 both encode isoform secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. The coding regions of variants 3 and 4 do not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript NESPAS.
    Source sequence(s)
    AJ010163, AK039035, AK132636, BU516278
    Consensus CDS
    CCDS17149.1
    UniProtKB/Swiss-Prot
    Q9Z0F1
    Related
    ENSMUSP00000104724.3, ENSMUST00000109096.9
    Conserved Domains (1) summary
    pfam06390
    Location:1253
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
  9. NM_201616.3NP_963910.1  protein GNAS isoform GNASL

    See identical proteins and their annotated locations for NP_963910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is biallelically expressed and encodes guanine nucleotide binding protein alpha-s long (GNASL) isoform, also known as alpha-S2, a form of the G-protein alpha subunit. Variants 7 and 10 encode the same isoform (GNASL).
    Source sequence(s)
    AK159563, AK168996, AL593857, BU516278, CK625094
    Consensus CDS
    CCDS38356.1
    UniProtKB/Swiss-Prot
    P63094
    Related
    ENSMUSP00000104715.2, ENSMUST00000109087.8
    Conserved Domains (1) summary
    cd00066
    Location:41388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  10. NM_201617.2NP_963911.1  protein GNAS isoform XXLb1

    See identical proteins and their annotated locations for NP_963911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is paternally expressed. Its 5' exon overlaps with variant 1 and none of its sequence overlaps with variant 7. This variant encodes isoform XXLb1, which has a distinct and shorter C-terminus, compared to isoform XLas. This variant is based on data in PMID:15148396.
    Source sequence(s)
    AK030489, AL593857
    Consensus CDS
    CCDS38355.1
    UniProtKB/Swiss-Prot
    Q6R0H6, Q6R0H7
    Related
    ENSMUSP00000085185.5, ENSMUST00000087877.11
    Conserved Domains (2) summary
    smart00275
    Location:759786
    G_alpha; G protein alpha subunit
    PRK12323
    Location:330531
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
  11. NM_201618.2NP_963912.1  protein ALEX isoform Alex

    See identical proteins and their annotated locations for NP_963912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as GNASXL) is paternally expressed. It includes an alternate 5' exon, compared to variant 7. This variant includes two overlapping open reading frames encoding XLas and Alex, respectively. This RefSeq represents isoform Alex (also known as alexX), which has no similarity to other isoforms encoded by this gene. It interacts with isoform XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells.
    Source sequence(s)
    AK132636, AL593857, BU516278
    Consensus CDS
    CCDS50817.1
    UniProtKB/Swiss-Prot
    Q6R0H6
    Related
    ENSMUSP00000139839.2, ENSMUST00000186907.7
    Conserved Domains (1) summary
    PHA03247
    Location:380674
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_003258.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as Exon1A) is paternally expressed and has two alternate 5' exons, compared to variant 7. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 7. This variant is described in PMID:19412439 and it may regulate imprinting of the GNAS transcripts.
    Source sequence(s)
    AL593857

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    174126113..174188537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498778.3XP_006498841.1  protein GNAS isoform X4

    Conserved Domains (1) summary
    cd00066
    Location:5341
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  2. XM_006498777.2XP_006498840.1  protein GNAS isoform X3

    Conserved Domains (1) summary
    cd00066
    Location:5357
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  3. XM_006498780.2XP_006498843.1  protein GNAS isoform X7

    Conserved Domains (3) summary
    cd00066
    Location:7801112
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    PHA03247
    Location:50496
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:330531
    PRK12323; DNA polymerase III subunit gamma/tau
  4. XM_017315658.2XP_017171147.1  protein GNAS isoform X5

    Related
    ENSMUSP00000158707.2, ENSMUST00000156623.8
    Conserved Domains (1) summary
    cd00066
    Location:1329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  5. XM_030247568.1XP_030103428.1  protein GNAS isoform X2

    Conserved Domains (1) summary
    cd00066
    Location:41388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  6. XM_030247569.2XP_030103429.1  protein GNAS isoform X6

    Conserved Domains (1) summary
    cd00066
    Location:1314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  7. XM_006498774.3XP_006498837.1  protein GNAS isoform X1

    Conserved Domains (1) summary
    cd00066
    Location:41389
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RNA

  1. XR_374414.4 RNA Sequence

  2. XR_003950807.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010310.1: Suppressed sequence

    Description
    NM_010310.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.
Support Center