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PROCA1 protein interacting with cyclin A1 [ Homo sapiens (human) ]

Gene ID: 147011, updated on 3-Apr-2024

Summary

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Official Symbol
PROCA1provided by HGNC
Official Full Name
protein interacting with cyclin A1provided by HGNC
Primary source
HGNC:HGNC:28600
See related
Ensembl:ENSG00000167525 MIM:617376; AllianceGenome:HGNC:28600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables cyclin binding activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 33.9) and spleen (RPKM 1.8) See more
Orthologs
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Genomic context

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Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28703197..28711888, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29645981..29654697, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27030215..27038906, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene stromal cell derived factor 2 Neighboring gene ribosomal protein S12 pseudogene 28 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:26988611-26989810 Neighboring gene SPT6 homolog, histone chaperone and transcription elongation factor Neighboring gene Sharpr-MPRA regulatory region 10516 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:27037571-27038346 and GRCh37_chr17:27038347-27039122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27045659-27046259 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27046260-27046861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11939 Neighboring gene RAB34, member RAS oncogene family Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene ribosomal protein L23a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs S, et al. J Biol Chem, 2004 Aug 6. PMID 15159402
  2. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Noguchi A, et al. Biol Open, 2018 Mar 12. PMID 29449217, Free PMC Article
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC39650

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein PROCA1
Names
proline-rich cyclin A1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304949.2 → NP_001291878.1  protein PROCA1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AI797917, BC029574, CR984201, HY044209
    UniProtKB/Swiss-Prot
    B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
    Conserved Domains (1) summary
    cd04705
    Location:17 → 95
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

  2. NM_001304951.2 → NP_001291880.1  protein PROCA1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AI797917, BC029574, BQ215318, HY044209
    UniProtKB/Swiss-Prot
    Q8NCQ7

  3. NM_001304952.2 → NP_001291881.1  protein PROCA1 isoform d

    See identical proteins and their annotated locations for NP_001291881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure, and it thus differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AC010761, AI797917, AK301868, BC029574, DB038438
    UniProtKB/Swiss-Prot
    B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
    Conserved Domains (1) summary
    cd04705
    Location:7 → 106
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

  4. NM_001304953.2 → NP_001291882.1  protein PROCA1 isoform e

    See identical proteins and their annotated locations for NP_001291882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon but contains a different internal exon, and it also uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a. Variants 5, 6 and 9 encode isoform e.
    Source sequence(s)
    AI797917, BC029574, CD300282, HY044209
    UniProtKB/Swiss-Prot
    Q8NCQ7

  5. NM_001304954.2 → NP_001291883.1  protein PROCA1 isoform e

    See identical proteins and their annotated locations for NP_001291883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains alternate 5' exon structure and it also uses an alternate splice site, resulting in an alternate 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a. Variants 5, 6 and 9 encode isoform e.
    Source sequence(s)
    AC010761, AI797917, AK310299, BC029574, DB038438
    UniProtKB/Swiss-Prot
    Q8NCQ7

  6. NM_001366301.1 → NP_001353230.1  protein PROCA1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC010761
    Consensus CDS
    CCDS92283.1
    UniProtKB/Swiss-Prot
    B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
    UniProtKB/TrEMBL
    A0A804HIV4
    Related
    ENSP00000507242.1, ENST00000682792.1
    Conserved Domains (1) summary
    cd04705
    Location:33 → 132
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

  7. NM_001366302.1 → NP_001353231.1  protein PROCA1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC010761
    UniProtKB/Swiss-Prot
    B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
    Conserved Domains (1) summary
    cl05417
    Location:6 → 78
    PLA2_like; PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  8. NM_001366303.1 → NP_001353232.1  protein PROCA1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes isoform e. Variants 5, 6 and 9 encode isoform e.
    Source sequence(s)
    AC010761
    Related
    ENST00000674362.1

  9. NM_152465.3 → NP_689678.1  protein PROCA1 isoform b

    See identical proteins and their annotated locations for NP_689678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AI797917, BC029574, HY044209
    Consensus CDS
    CCDS11239.1
    UniProtKB/Swiss-Prot
    B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
    Related
    ENSP00000301039.2, ENST00000301039.6
    Conserved Domains (1) summary
    cd04705
    Location:5 → 104
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    28703197..28711888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435477.1 → XP_047291433.1  protein PROCA1 isoform X2

  2. XM_006721723.4 → XP_006721786.1  protein PROCA1 isoform X1

    UniProtKB/Swiss-Prot
    B4DX95, G5E9R8, Q6PKN3, Q8NCQ7
    Conserved Domains (1) summary
    cd04705
    Location:33 → 132
    PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...

  3. XM_047435476.1 → XP_047291432.1  protein PROCA1 isoform X2

  4. XM_047435473.1 → XP_047291429.1  protein PROCA1 isoform X2

  5. XM_047435475.1 → XP_047291431.1  protein PROCA1 isoform X2

  6. XM_047435474.1 → XP_047291430.1  protein PROCA1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    29645981..29654697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315232.1 → XP_054171207.1  protein PROCA1 isoform X2

  2. XM_054315227.1 → XP_054171202.1  protein PROCA1 isoform X1

  3. XM_054315231.1 → XP_054171206.1  protein PROCA1 isoform X2

  4. XM_054315228.1 → XP_054171203.1  protein PROCA1 isoform X2

  5. XM_054315230.1 → XP_054171205.1  protein PROCA1 isoform X2

  6. XM_054315229.1 → XP_054171204.1  protein PROCA1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCQ7.3 GenPept UniProtKB/Swiss-Prot:Q8NCQ7

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