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Lrp2 low density lipoprotein receptor-related protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14725, updated on 21-Oct-2021

Summary

Official Symbol
Lrp2provided by MGI
Official Full Name
low density lipoprotein receptor-related protein 2provided by MGI
Primary source
MGI:MGI:95794
See related
Ensembl:ENSMUSG00000027070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gp330; Megalin; AI315343; AW536255; b2b1625.2Clo; D230004K18Rik
Expression
Biased expression in kidney adult (RPKM 131.9) and placenta adult (RPKM 33.9) See more
Orthologs
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Genomic context

See Lrp2 in Genome Data Viewer
Location:
2 C2; 2 40.74 cM
Exon count:
79
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69254679..69416373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69424335..69586029, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (69262392..69424124, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11 Neighboring gene predicted gene, 36393 Neighboring gene dehydrogenase/reductase (SDR family) member 9 Neighboring gene Bardet-Biedl syndrome 5 (human) Neighboring gene kelch-like 41

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables hemoglobin binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chemoattraction of axon ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytic hemoglobin import into cell ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in folate import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metal ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipoprotein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oligodendrocyte progenitor proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to X-ray ISO
Inferred from Sequence Orthology
more info
 
involved_in response to leptin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to leptin ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary heart field specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in vagina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular compact myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vitamin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
low-density lipoprotein receptor-related protein 2
Names
glycoprotein 330

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081088.2NP_001074557.1  low-density lipoprotein receptor-related protein 2 precursor

    See identical proteins and their annotated locations for NP_001074557.1

    Status: VALIDATED

    Source sequence(s)
    AL845489
    Consensus CDS
    CCDS38135.1
    UniProtKB/Swiss-Prot
    A2ARV4
    Related
    ENSMUSP00000079752.6, ENSMUST00000080953.12
    Conserved Domains (9) summary
    smart00192
    Location:29082939
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:15021544
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:13911430
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:37613795
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:10651101
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:33353375
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:31343157
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:13541389
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:31493192
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    69254679..69416373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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