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Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B [ Mus musculus (house mouse) ]

Gene ID: 14727, updated on 11-Apr-2024

Summary

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Official Symbol
Lilrb4bprovided by MGI
Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B, member 4Bprovided by MGI
Primary source
MGI:MGI:102702
See related
Ensembl:ENSMUSG00000112023 AllianceGenome:MGI:102702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gp49; Gp49a; Lilr4b
Summary
Predicted to enable protein phosphatase binding activity and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; regulation of leukocyte activation; and regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 4.8), mammary gland adult (RPKM 4.7) and 21 other tissues See more
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Genomic context

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Location:
10 B3; 10 25.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51356757..51362417)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (51480612..51486329)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26656 Neighboring gene STARR-seq mESC enhancer starr_26657 Neighboring gene predicted gene, 53627 Neighboring gene STARR-seq mESC enhancer starr_26658 Neighboring gene leukocyte immunoglobulin-like receptor subfamily A member 6 Neighboring gene STARR-seq mESC enhancer starr_26659 Neighboring gene predicted gene, 40645 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily B, member 4A Neighboring gene predicted gene, 46224

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells. Lee KH, et al. J Immunol, 2000 Nov 1. PMID 11046024
  2. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. Arm JP, et al. J Biol Chem, 1991 Aug 25. PMID 1714901
  3. Natural killer cells and mast cells from gp49B null mutant mice are functional. Rojo S, et al. Mol Cell Biol, 2000 Oct. PMID 10982834, Free PMC Article
  4. The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily. McCormick MJ, et al. Immunogenetics, 1999 Dec. PMID 10630292
  5. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. Castells MC, et al. J Biol Chem, 1994 Mar 18. PMID 8132564

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
    Title: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Fc receptor mediated inhibitory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytotoxic T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of monocyte activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in tolerance induction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 4B
Names
glycoprotein 49 A
mast cell surface glycoprotein Gp49A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291892.2 → NP_001278821.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153530
    Conserved Domains (1) summary
    cl11960
    Location:37 → 131
    Ig; Immunoglobulin domain

  2. NM_001291893.2 → NP_001278822.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 3 precursor

    See identical proteins and their annotated locations for NP_001278822.1

    Status: VALIDATED

    Source sequence(s)
    AC153530
    Consensus CDS
    CCDS88004.1
    UniProtKB/TrEMBL
    A0A1W2P6F1, A0A1W2P7F3
    Related
    ENSMUSP00000151625.2, ENSMUST00000219661.2
    Conserved Domains (1) summary
    cl11960
    Location:29 → 123
    Ig; Immunoglobulin domain

  3. NM_001419401.1 → NP_001406330.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153530

  4. NM_008147.3 → NP_032173.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor

    See identical proteins and their annotated locations for NP_032173.1

    Status: VALIDATED

    Source sequence(s)
    AC153530
    Consensus CDS
    CCDS23831.1
    UniProtKB/Swiss-Prot
    Q549E3, Q61450
    UniProtKB/TrEMBL
    A0A1W2P7X1
    Related
    ENSMUSP00000099958.4, ENSMUST00000102894.6
    Conserved Domains (1) summary
    cl11960
    Location:124 → 218
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    51356757..51362417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61450.1 GenPept UniProtKB/Swiss-Prot:Q61450

Gene LinkOut

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