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Gpx3 glutathione peroxidase 3 [ Mus musculus (house mouse) ]

Gene ID: 14778, updated on 16-Aug-2021

Summary

Official Symbol
Gpx3provided by MGI
Official Full Name
glutathione peroxidase 3provided by MGI
Primary source
MGI:MGI:105102
See related
Ensembl:ENSMUSG00000018339
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GP; EGP; GPx; EGPx; GSHPx-3; GSHPx-P; AA960521
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]
Expression
Biased expression in kidney adult (RPKM 11946.2) and genital fat pad adult (RPKM 610.3) See more
Orthologs
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Genomic context

See Gpx3 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54793680..54801213)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54902854..54910387)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54716355..54723889)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1343 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene 40S ribosomal protein S11-like Neighboring gene annexin A6 Neighboring gene predicted gene, 19911

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables selenium binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables selenium binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione peroxidase 3
Names
GPx-3
GPx-P
extracellular GPx
plasma GPx
plasma glutathione peroxidase
NP_001316789.1
NP_032187.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329860.1NP_001316789.1  glutathione peroxidase 3 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional in-frame coding exon compared to variant 1. The resulting isoform (2) is longer, containing a 32 aa protein segment not found in isoform 1.
    Source sequence(s)
    AK004942, AW319411, BG796554, BY061328
    UniProtKB/Swiss-Prot
    P46412
    Related
    ENSMUSP00000119882.3, ENSMUST00000149324.3
  2. NM_008161.4NP_032187.2  glutathione peroxidase 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032187.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AK004942, BG796554, BY061328
    Consensus CDS
    CCDS24703.1
    UniProtKB/Swiss-Prot
    P46412
    Related
    ENSMUSP00000081011.5, ENSMUST00000082430.11
    Conserved Domains (1) summary
    cd00340
    Location:39211
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54793680..54801213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001083929.1: Suppressed sequence

    Description
    NM_001083929.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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