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ZNF420 zinc finger protein 420 [ Homo sapiens (human) ]

Gene ID: 147923, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF420provided by HGNC
Official Full Name
zinc finger protein 420provided by HGNC
Primary source
HGNC:HGNC:20649
See related
Ensembl:ENSG00000197050 MIM:617216; AllianceGenome:HGNC:20649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APAK
Summary
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis (RPKM 3.6), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37007902..37130368)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39682827..39805340)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37569124..37621270)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 568 Neighboring gene uncharacterized LOC105372390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14538 Neighboring gene zinc finger protein 585A Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Outlier Analysis Defines Zinc Finger Gene Family DNA Methylation in Tumors and Saliva of Head and Neck Cancer Patients. Gaykalova DA, et al. PLoS One, 2015. PMID 26544568, Free PMC Article
  2. Differential regulation of Apak by various DNA damage signals. Wang S, et al. Mol Cell Biochem, 2010 Jan. PMID 19629643
  3. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Tian C, et al. Nat Cell Biol, 2009 May. PMID 19377469
  4. H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. Olcina MM, et al. Oncogene, 2016 Feb 11. PMID 25961932, Free PMC Article
  5. Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. Yuan L, et al. EMBO Rep, 2012 Apr. PMID 22334068, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional importance of H3K9me3 in hypoxia, apoptosis and repression of APAK.
    Title: H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.
  2. ARF coordinates Apak to regulate ribosome biogenesis upon cellular stress.
    Title: ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.
  3. Apak competes with p53 for binding to inhibit p53AIP1 expression.
    Title: Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.
  4. Apak is differentially regulated in the ARF and ATM-dependent manner in response to oncogenic stress and DNA damage, respectively.
    Title: ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
  5. four of seven types of DNA damage signals examined resulted in significant Apak phosphorylation and dissociation of Apak from p53, releasing the inhibition of p53 transcriptional activity
    Title: Differential regulation of Apak by various DNA damage signals.
  6. Apak (ZNF420 or FLJ32191) is a negative regulator of p53-mediated apoptosis.
    Title: KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 420
Names
ATM and p53-associated KZNF protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051212.1 RefSeqGene

    Range
    75619..127554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329515.3 → NP_001316444.1  zinc finger protein 420 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC010632, AC012309

  2. NM_001329516.3 → NP_001316445.1  zinc finger protein 420 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (5) summary
    smart00349
    Location:6 → 48
    KRAB; krueppel associated box
    COG5048
    Location:165 → 577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:434 → 458
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001329517.1 → NP_001316446.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform d, as do variants 5, 6, and 7.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001329518.1 → NP_001316447.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform d, as do variants 4, 6, and 7.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001329519.1 → NP_001316448.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes isoform d, as do variants 4, 5, and 7.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001329520.1 → NP_001316449.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform d, as do variants 4, 5, and 6.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001329521.3 → NP_001316450.1  zinc finger protein 420 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:503 → 527
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001329522.3 → NP_001316451.1  zinc finger protein 420 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309, AK056753
    Consensus CDS
    CCDS86757.1
    UniProtKB/Swiss-Prot
    Q8TAQ5
    Related
    ENSP00000306102.7, ENST00000304239.11
    Conserved Domains (6) summary
    smart00349
    Location:6 → 48
    KRAB; krueppel associated box
    COG5048
    Location:137 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:223 → 245
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:434 → 458
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001329524.3 → NP_001316453.1  zinc finger protein 420 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309

  10. NM_144689.5 → NP_653290.2  zinc finger protein 420 isoform b

    See identical proteins and their annotated locations for NP_653290.2

    Status: REVIEWED

    Source sequence(s)
    AC012309, AK315728
    Consensus CDS
    CCDS12498.1
    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5
    Related
    ENSP00000338770.2, ENST00000337995.4
    Conserved Domains (4) summary
    COG5048
    Location:165 → 577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589 → 609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:629 → 654
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_138039.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010632

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37007902..37130368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438230.1 → XP_047294186.1  zinc finger protein 420 isoform X1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5

  2. XM_011526503.3 → XP_011524805.1  zinc finger protein 420 isoform X1

    See identical proteins and their annotated locations for XP_011524805.1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5
    Conserved Domains (4) summary
    COG5048
    Location:165 → 577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589 → 609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:629 → 654
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011526510.3 → XP_011524812.1  zinc finger protein 420 isoform X3

    See identical proteins and their annotated locations for XP_011524812.1

    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047438229.1 → XP_047294185.1  zinc finger protein 420 isoform X1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5

  5. XM_011526507.4 → XP_011524809.1  zinc finger protein 420 isoform X3

    See identical proteins and their annotated locations for XP_011524809.1

    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011526504.3 → XP_011524806.1  zinc finger protein 420 isoform X1

    See identical proteins and their annotated locations for XP_011524806.1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5
    Conserved Domains (4) summary
    COG5048
    Location:165 → 577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589 → 609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:629 → 654
    zf-H2C2_2; Zinc-finger double domain

  7. XM_011526508.3 → XP_011524810.1  zinc finger protein 420 isoform X3

    See identical proteins and their annotated locations for XP_011524810.1

    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

  8. XM_006723038.4 → XP_006723101.1  zinc finger protein 420 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:6 → 48
    KRAB; krueppel associated box
    COG5048
    Location:165 → 577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:434 → 458
    zf-H2C2_2; Zinc-finger double domain

  9. XM_011526511.3 → XP_011524813.1  zinc finger protein 420 isoform X5

    Conserved Domains (5) summary
    smart00349
    Location:6 → 48
    KRAB; krueppel associated box
    COG5048
    Location:137 → 477
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:434 → 458
    zf-H2C2_2; Zinc-finger double domain

  10. XM_047438232.1 → XP_047294188.1  zinc finger protein 420 isoform X5

  11. XM_047438231.1 → XP_047294187.1  zinc finger protein 420 isoform X4

  12. XM_017026338.2 → XP_016881827.1  zinc finger protein 420 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:94 → 506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558 → 583
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39682827..39805340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319914.1 → XP_054175889.1  zinc finger protein 420 isoform X3

  2. XM_054319909.1 → XP_054175884.1  zinc finger protein 420 isoform X1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5

  3. XM_054319908.1 → XP_054175883.1  zinc finger protein 420 isoform X1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5

  4. XM_054319906.1 → XP_054175881.1  zinc finger protein 420 isoform X1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5

  5. XM_054319912.1 → XP_054175887.1  zinc finger protein 420 isoform X3

  6. XM_054319907.1 → XP_054175882.1  zinc finger protein 420 isoform X1

    UniProtKB/Swiss-Prot
    B2RDY6, Q8TAQ5, Q96ML5

  7. XM_054319911.1 → XP_054175886.1  zinc finger protein 420 isoform X3

  8. XM_054319910.1 → XP_054175885.1  zinc finger protein 420 isoform X2

  9. XM_054319915.1 → XP_054175890.1  zinc finger protein 420 isoform X5

  10. XM_054319916.1 → XP_054175891.1  zinc finger protein 420 isoform X5

  11. XM_054319913.1 → XP_054175888.1  zinc finger protein 420 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TAQ5.1 GenPept UniProtKB/Swiss-Prot:Q8TAQ5

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