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CAPN12 calpain 12 [ Homo sapiens (human) ]

Gene ID: 147968, updated on 11-Sep-2019

Summary

Official Symbol
CAPN12provided by HGNC
Official Full Name
calpain 12provided by HGNC
Primary source
HGNC:HGNC:13249
See related
Ensembl:ENSG00000182472 MIM:608839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in gall bladder (RPKM 14.2), spleen (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See CAPN12 in Genome Data Viewer
Location:
19q13.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38730048..38744474, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39220832..39235114, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene actinin alpha 4 Neighboring gene uncharacterized LOC107985291 Neighboring gene galectin 7 Neighboring gene galectin 7B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of calpain 12 (CAPN12) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...

General gene information

Markers

Homology

Clone Names

  • MGC20576

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calpain-12
Names
CANP 12
calcium-activated neutral proteinase 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144691.4NP_653292.2  calpain-12

    See identical proteins and their annotated locations for NP_653292.2

    Status: VALIDATED

    Source sequence(s)
    AC022144, AK127398, BE872274, DA384049
    Consensus CDS
    CCDS12519.1
    UniProtKB/Swiss-Prot
    Q6ZSI9
    Related
    ENSP00000331636.3, ENST00000328867.8
    Conserved Domains (3) summary
    cd00214
    Location:352530
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:46339
    Peptidase_C2; Calpain family cysteine protease
    cl08302
    Location:626681
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38730048..38744474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026364.1XP_016881853.1  calpain-12 isoform X10

    Related
    ENSP00000473156.1, ENST00000601953.5
  2. XM_017026357.2XP_016881846.1  calpain-12 isoform X3

  3. XM_017026360.2XP_016881849.1  calpain-12 isoform X6

  4. XM_017026356.2XP_016881845.1  calpain-12 isoform X2

  5. XM_017026355.2XP_016881844.1  calpain-12 isoform X1

  6. XM_017026358.2XP_016881847.1  calpain-12 isoform X4

  7. XM_017026363.2XP_016881852.1  calpain-12 isoform X9

  8. XM_017026359.2XP_016881848.1  calpain-12 isoform X5

  9. XM_017026362.2XP_016881851.1  calpain-12 isoform X8

  10. XM_017026361.2XP_016881850.1  calpain-12 isoform X7

  11. XM_017026365.2XP_016881854.1  calpain-12 isoform X11

RNA

  1. XR_001753609.2 RNA Sequence

  2. XR_001753611.2 RNA Sequence

  3. XR_001753608.2 RNA Sequence

  4. XR_001753607.2 RNA Sequence

  5. XR_001753610.2 RNA Sequence

  6. XR_001753606.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p13 PATCHES

    Range
    139828..154078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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