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ZNF738 zinc finger protein 738 [ Homo sapiens (human) ]

Gene ID: 148203, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF738provided by HGNC
Official Full Name
zinc finger protein 738provided by HGNC
Primary source
HGNC:HGNC:32469
See related
Ensembl:ENSG00000172687 AllianceGenome:HGNC:32469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.4), lymph node (RPKM 1.2) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21359000..21388582)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21497531..21527122)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21541802..21571384)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene COX16 pseudogene 1 Neighboring gene vomeronasal 1 receptor 83 pseudogene Neighboring gene zinc finger protein 708 Neighboring gene NANOG hESC enhancer GRCh37_chr19:21500539-21501043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21510155-21510676 Neighboring gene BCL2 interacting protein 3 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14383 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21512069-21513057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21540515-21541072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14385 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:21579974-21580212 Neighboring gene zinc finger protein 493 Neighboring gene MPRA-validated peak3410 silencer Neighboring gene uncharacterized LOC105372321 Neighboring gene MPRA-validated peak3411 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21643213-21643712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21646023-21646921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 738
Names
protein ZNF738

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355237.2 → NP_001342166.1  zinc finger protein 738 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010615, AC022432
    Consensus CDS
    CCDS92573.1
    UniProtKB/Swiss-Prot
    A8K4N7, Q8NE65
    UniProtKB/TrEMBL
    A0A804HJ59
    Related
    ENSP00000507366.1, ENST00000683779.1
    Conserved Domains (3) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box
    COG5048
    Location:149 → 374
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001355239.2 → NP_001342168.1  zinc finger protein 738 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010615, AC022432
    Consensus CDS
    CCDS86732.1
    Related
    ENSP00000311957.3, ENST00000311015.7
    Conserved Domains (1) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box

  3. NM_001355240.2 → NP_001342169.1  zinc finger protein 738 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC010615, AC022432
    Consensus CDS
    CCDS86733.1
    UniProtKB/TrEMBL
    E9PE46, M0R0N2
    Related
    ENSP00000370252.4, ENST00000380870.8
    Conserved Domains (1) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box

  4. NM_001355241.2 → NP_001342170.1  zinc finger protein 738 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC010615, AC022432
    UniProtKB/TrEMBL
    M0R0N2
    Related
    ENSP00000471336.1, ENST00000597810.5
    Conserved Domains (1) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    21359000..21388582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438272.1 → XP_047294228.1  zinc finger protein 738 isoform X1

  2. XM_047438273.1 → XP_047294229.1  zinc finger protein 738 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    21497531..21527122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320000.1 → XP_054175975.1  zinc finger protein 738 isoform X1

  2. XM_054320001.1 → XP_054175976.1  zinc finger protein 738 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NE65.2 GenPept UniProtKB/Swiss-Prot:Q8NE65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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