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Grn granulin [ Mus musculus (house mouse) ]

Gene ID: 14824, updated on 28-Jun-2021

Summary

Official Symbol
Grnprovided by MGI
Official Full Name
granulinprovided by MGI
Primary source
MGI:MGI:95832
See related
Ensembl:ENSMUSG00000034708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P; pr; GP88; PEPI; Pgrn; epit; PCDGF; epithelin
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 113.5), ovary adult (RPKM 110.4) and 28 other tissues See more
Orthologs
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Genomic context

See Grn in Genome Data Viewer
Location:
11 D; 11 66.29 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102321333..102327635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102430507..102436809)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (102291636..102298123)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3A Neighboring gene solute carrier family 25, member 39 Neighboring gene microRNA 6930 Neighboring gene family with sequence similarity 171, member A2 Neighboring gene integrin alpha 2b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in astrocyte activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst hatching IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lysosomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male mating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of respiratory burst involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of aspartic-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of aspartic-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lysosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lysosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
progranulin
Names
PC cell-derived growth factor
acrogranin
acrogranulin
epithelin/granulin
glycoprotein 88
glycoprotein of 88 Kda
granulins
proepithelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008175.5NP_032201.3  progranulin precursor

    Status: VALIDATED

    Source sequence(s)
    AK018744, AK152705, AW456643
    Related
    ENSMUSP00000159379.2, ENSMUST00000239431.2
    Conserved Domains (1) summary
    smart00277
    Location:283333
    GRAN; Granulin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102321333..102327635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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