Gspt2 G1 to S phase transition 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gspt2provided by MGI
Official Full Name: G1 to S phase transition 2provided by MGI
Primary source: MGI:MGI:1316727
See related: Ensembl:ENSMUSG00000071723 AllianceGenome:MGI:1316727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in cytoplasmic translational termination. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in adrenal gland; genitourinary system; intestine; and spinal cord. Orthologous to human GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: X C3; X 41.63 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (93679675..93682168)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (94636069..94638562)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables translation release factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation release factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational termination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of translation release factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Names: G1 to S phase transition protein 2 homolog; eRF3b; eukaryotic peptide chain release factor subunit 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008179.2 → NP_032205.2 eukaryotic peptide chain release factor GTP-binding subunit ERF3B

See identical proteins and their annotated locations for NP_032205.2

Status: VALIDATED

Source sequence(s)

AL645466, AW125523

Consensus CDS

CCDS41064.1

UniProtKB/Swiss-Prot

O88180, Q149F3, Q9CY91

Related

ENSMUSP00000109523.2, ENSMUST00000096368.4

Conserved Domains (5) summary

cd01883
Location:209 → 425

EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family

COG5256
Location:205 → 629

TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

pfam07145
Location:54 → 71

PAM2; Ataxin-2 C-terminal region

cd04089
Location:434 → 514

eRF3_II; Domain II of the eukaryotic class II release factor

cd03704
Location:521 → 627

eRF3_C_III; C-terminal domain of eRF3