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ORF62 transcriptional regulator ICP4 [ Human alphaherpesvirus 3 (Varicella-zoster virus) ]

Gene ID: 1487699, updated on 18-Aug-2023

Summary

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Gene symbol
ORF62
Gene description
transcriptional regulator ICP4
Locus tag
HHV3_gp63
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 3 (strain: Dumas, acronym: HHV-3, acronym: VZV, nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_001348.1 (105141..109133, complement)

NC_001348.1Genomic Context describing neighboring genes Neighboring gene protein V57 Neighboring gene nuclear protein UL3 Neighboring gene uracil-DNA glycosylase Neighboring gene envelope glycoprotein L Neighboring gene ubiquitin E3 ligase ICP0 Neighboring gene regulatory protein ICP22 Neighboring gene virion protein US10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001348.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation. Khalil MI, et al. Virology, 2014 Jan 20. PMID 24418559, Free PMC Article
  2. Cyclin-dependent kinase 1/cyclin B1 phosphorylates varicella-zoster virus IE62 and is incorporated into virions. Leisenfelder SA, et al. J Virol, 2008 Dec. PMID 18799590, Free PMC Article
  3. The complete DNA sequence of varicella-zoster virus. Davison AJ, et al. J Gen Virol, 1986 Sep. PMID 3018124

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cellular factor YY1 played role in varicella-zoster virus replication through the mediation of IE62 activation of viral gene expression.
    Title: Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation.
  2. IE62 is a substrate for CDK1/cyclin B1, and virions could deliver the active cellular kinase to nondividing cells that normally do not express it
    Title: Cyclin-dependent kinase 1/cyclin B1 phosphorylates varicella-zoster virus IE62 and is incorporated into virions.
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General gene information

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regulatory

  • Loc: c105147-105141 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
transcriptional regulator ICP4
NP_040184.1

VOG classification

Description:

  • VOGd0148 [T] Immediate-early gene transactivator/major membrane glycoprotein (split)
  • RNA Replication, Transcription and Modification

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001348.1 Reference assembly

    Range
    105141..109133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040184.1 transcriptional regulator ICP4 [Human alphaherpesvirus 3]

    See identical proteins and their annotated locations for NP_040184.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P09310
    UniProtKB/TrEMBL
    A0A0F7CVI7, A0A0F7GJ31, A6XEF1, Q6X674, Q98WV5, Q9DK02
    Conserved Domains (1) summary
    PHA03307
    Location:16 → 1180
    PHA03307; transcriptional regulator ICP4; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
CAA27945.1

Gene LinkOut

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