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ORF54 capsid portal protein [ Human alphaherpesvirus 3 (Varicella-zoster virus) ]

Gene ID: 1487723, updated on 18-Aug-2023

Summary

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Gene symbol
ORF54
Gene description
capsid portal protein
Locus tag
HHV3_gp55
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 3 (strain: Dumas, acronym: HHV-3, acronym: VZV, nat-host: Homo sapiens)
Lineage
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_001348.1 (92850..95984, complement)

NC_001348.1Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein M Neighboring gene DNA replication origin-binding helicase Neighboring gene helicase-primase subunit Neighboring gene tegument protein UL7 Neighboring gene helicase-primase helicase subunit Neighboring gene nuclear protein UL4 Neighboring gene protein V57 Neighboring gene nuclear protein UL3 Neighboring gene uracil-DNA glycosylase Neighboring gene envelope glycoprotein L

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001348.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The varicella-zoster virus portal protein is essential for cleavage and packaging of viral DNA. Visalli MA, et al. J Virol, 2014 Jul. PMID 24807720, Free PMC Article
  2. Non-axial view of the varicella-zoster virus portal protein reveals conserved crown, wing and clip architecture. Visalli RJ, et al. Intervirology, 2014. PMID 24642670, Free PMC Article
  3. The Varicella-zoster virus ORF54 gene product encodes the capsid portal protein, pORF54. Howard AJ, et al. Virus Res, 2012 Jul. PMID 22475744, Free PMC Article
  4. The complete DNA sequence of varicella-zoster virus. Davison AJ, et al. J Gen Virol, 1986 Sep. PMID 3018124

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that pORF54 forms higher-order structures with itself.
    Title: Non-axial view of the varicella-zoster virus portal protein reveals conserved crown, wing and clip architecture.
  2. This result demonstrates that an ORF54 deletion mutant virus is not able to process and package viral DNA, thus making pORF54 an excellent chemotherapeutic target.
    Title: The varicella-zoster virus portal protein is essential for cleavage and packaging of viral DNA.
  3. ORF54 gene product encodes the capsid portal protein.
    Title: The Varicella-zoster virus ORF54 gene product encodes the capsid portal protein, pORF54.
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General gene information

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Homology

regulatory

  • Loc: c92855-92850 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
capsid portal protein
NP_040176.1

VOG classification

Description:

  • VOGd0051 [S] Minor capsid protein UL6
  • Structural Proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001348.1 Reference assembly

    Range
    92850..95984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040176.1 capsid portal protein [Human alphaherpesvirus 3]

    See identical proteins and their annotated locations for NP_040176.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P09302
    UniProtKB/TrEMBL
    A0A0F7GIU7, A0A0F7GMC7, A0A0F7GNC1, A0A0F7GNG9, A0A4D6EYG1, G0ZLF6, G9IUW1, G9IWH8, G9IXI8, G9IXY2, G9IY54, Q2PJ11, Q4JQS1, Q6QCK2, Q77NP0
    Conserved Domains (1) summary
    pfam01763
    Location:74 → 643
    Herpes_UL6; Herpesvirus UL6 like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
CAA27937.1

Gene LinkOut

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