E1 E1 [Bos taurus papillomavirus 1] - Gene

Summary

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Gene symbol: E1
Gene description: E1
Locus tag: BPVgp3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus papillomavirus 1
Lineage: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Deltapapillomavirus; Deltapapillomavirus 4
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Genomic context

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Sequence:: NC_001522.1 (849..2666)

NC_001522.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001522.1

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of a conserved lysine residue in the smaller tier or collar of the E1 helicase domain in ori processing is described.
Title: A DNA-binding activity in BPV initiator protein E1 required for melting duplex ori DNA but not processive helicase activity initiated on partially single-stranded DNA.
In this report we identify three functional nuclear export sequences (NES) present in BPV E1, with NES2 being the strongest in reporter assays.
Title: Identification of a nuclear export signal sequence for bovine papillomavirus E1 protein.
The ATP-binding sites of the E1 helicase adopt specific conformations linked to positional changes in the DNA-binding hairpins, which follow a wave-like trajectory, as observed previously in the E1/DNA/ADP complex.
Title: Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors.
results suggest that Topo I participates in the initiation of papillomavirus DNA replication by enhancing E1 binding to the BPV1 origin
Title: Cellular topoisomerase I modulates origin binding by bovine papillomavirus type 1 E1.
Dimerization between E1 DNA binding domains has a severe effect on DNA replication.
Title: Role of papillomavirus E1 initiator dimerization in DNA replication.
The characterization of the enzymatic, oligomerization and DNA-binding properties of a helicase protein derived from the C-terminal domain of BPV E1 protein.
Title: Role of ATP hydrolysis in the DNA translocase activity of the bovine papillomavirus (BPV-1) E1 helicase.

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: E1

NP_056739.1

E1; The Papillomaviriuses are icosahedral dsDNA viruses that encode 7 early proteins, E1 to E7, and 2 late structural proteins L1 and L2. Host infection by members of the papillomaviruses gives rise to warts and cancer in some instances. The E1 helicase protein is an ATP-dependent DNA helicase that facilitates the inititiation of viral DNA replication through its interactions with the viral E2 protein. The E1-E2 complex binds to the viral origin of replication where E1 acts to unwind the DNA and E2 acts as a transcriptional activator.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001522.1 Reference assembly

Range

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_056739.1 E1 protein [Bos taurus papillomavirus 1]

See identical proteins and their annotated locations for NP_056739.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P03116, Q9WMH1

Conserved Domains (3) summary

PHA02774
Location:1 → 602

PHA02774; E1; Provisional

pfam00524
Location:1 → 121

PPV_E1_N; E1 Protein, N terminal domain

cl24009
Location:166 → 575

Parvo_NS1; Parvovirus non-structural protein NS1