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E5 E5 protein [ Bos taurus papillomavirus 1 ]

Gene ID: 1489021, updated on 29-Oct-2023

Summary

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Gene symbol
E5
Gene description
E5 protein
Locus tag
BPVgp6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus papillomavirus 1
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Deltapapillomavirus; Deltapapillomavirus 4
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Genomic context

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Sequence:
NC_001522.1 (3878..4012)

NC_001522.1Genomic Context describing neighboring genes Neighboring gene E7 protein Neighboring gene E1 Neighboring gene E2 protein Neighboring gene E4 protein Neighboring gene L2 protein Neighboring gene major capsid L1 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001522.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bovine papillomavirus E5 oncoprotein expression and its association with an interactor network in aggresome-autophagy pathway. Roperto S, et al. Vet Microbiol, 2019 Jun. PMID 31176410
  2. Towards a structural understanding of the smallest known oncoprotein: investigation of the bovine papillomavirus E5 protein using solution-state NMR. King G, et al. Biochim Biophys Acta, 2011 Jun. PMID 21073859
  3. In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain. Oates J, et al. Biochemistry, 2008 Aug 26. PMID 18672907, Free PMC Article
  4. Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction. Edwards AP, et al. J Virol, 2013 Oct. PMID 23926343, Free PMC Article
  5. Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. Talbert-Slagle K, et al. J Virol, 2009 Oct. PMID 19605488, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E5 oncoprotein of bovine Deltapapillomavirus interacts with a network of protein interactors responsible for an activation of autophagy in urothelial cells infected by BPVs
    Title: Bovine papillomavirus E5 oncoprotein expression and its association with an interactor network in aggresome-autophagy pathway.
  2. These results provide strong genetic evidence that the transmembrane domains of the E5 protein of bovine papillomavirus 1 and the platelet-derived growth factor beta receptor contact one another directly.
    Title: Compensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction.
  3. Data estimated the free energy of association (DeltaGx degrees =-3.05 kcal mol(-1)) for the dimerization of E5 in SDS micelles.
    Title: Towards a structural understanding of the smallest known oncoprotein: investigation of the bovine papillomavirus E5 protein using solution-state NMR.
  4. E5 and E6 were found to be responsible for the enhanced cell proliferation and induction of increased invasion in EqS02a cells, whilst E7 appeared to enhance cell anchorage independence.
    Title: Different contribution of bovine papillomavirus type 1 oncoproteins to the transformation of equine fibroblasts.
  5. analysis of specific features of BPV E5 important for its ability to activate the PDGF beta receptor and transform mouse fibroblasts
    Title: Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.
  6. Data show transmembrane (TM) domain of E5 adopts a stable alpha-helical structure and forms a strong dimer with a standard state free energy of dissociation of 5.0 kcal mol-1.
    Title: In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
E5 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001522.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056742.1 E5 protein [Bos taurus papillomavirus 1]

    See identical proteins and their annotated locations for NP_056742.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06928, P0CK45, P0CK46
    UniProtKB/TrEMBL
    J7K4X1, Q6XHB4, Q6XHC0
Protein Accession Links
GenPept Link UniProtKB Link
CAB46513.1

Gene LinkOut

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